Indian pediatrics · 2017
A Prospective Study of Homocysteine and its relation to Body Mass Index and Lipid Profile in School Children.
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Kumar K Jagadish, Saldanha Karen, Sushma K, Murthy D Srinivasa, Vishwanath Prashanth
Аннотация
OBJECTIVE: To study the serum Homocysteine levels in children and its relation with body mass index (BMI), lipid profile and plasma glucose.
METHODS: 138 children (age 5-15 y) were enrolled and categorized into normal, overweight and obese group. Blood homocysteine, lipid profile and plasma glucose were estimated.
RESULTS: Out of 138 children, 46 (33%) were normal, 40 (29%) were overweight and 52 (38%) were obese. Hyper-homocysteinemia was found in 34 (24.6%) of children. None of the normal children had hyperhomocysteinemia in contrast to 15 (37.5%) in overweight and 19 (36.5%) in obese group (P=0.001).The median homocysteine levels in obese and overweight children was significantly higher compared to normal children (P=0.001).There was a positive correlation between BMI and homocysteine levels. There was no significant correlation between lipid profile and plasma glucose with homocysteine levels.
CONCLUSION: Serum homocysteine levels are significantly higher in both overweight and obese children compared to normal children.
METHODS: 138 children (age 5-15 y) were enrolled and categorized into normal, overweight and obese group. Blood homocysteine, lipid profile and plasma glucose were estimated.
RESULTS: Out of 138 children, 46 (33%) were normal, 40 (29%) were overweight and 52 (38%) were obese. Hyper-homocysteinemia was found in 34 (24.6%) of children. None of the normal children had hyperhomocysteinemia in contrast to 15 (37.5%) in overweight and 19 (36.5%) in obese group (P=0.001).The median homocysteine levels in obese and overweight children was significantly higher compared to normal children (P=0.001).There was a positive correlation between BMI and homocysteine levels. There was no significant correlation between lipid profile and plasma glucose with homocysteine levels.
CONCLUSION: Serum homocysteine levels are significantly higher in both overweight and obese children compared to normal children.