Медицинская библиотека · Dementia and geriatric cognitive disorders · 2011

Paraoxonase 1 gene polymorphisms do not influence the response to treatment in Alzheimer's disease.

Klimkowicz-Mrowiec A, Marona M, Spisak K, Jagiella J, Wolkow P, Szczudlik A, Slowik A

СтатьяПеревод пока не подготовлен

Аннотация

BACKGROUND

Acetylcholinesterase inhibitors (AChEIs) are the treatment of choice for patients with Alzheimer's disease (AD). However, their efficacy is moderate and differs from patient to patient. Recent studies suggest that the Q192R variant of the paraoxonase 1 gene (PON1) might affect individual susceptibility to these drugs.

METHODS

We investigated the influence of 3 single nucleotide polymorphisms (SNPs) in PON1 (rs 662, rs 854560, rs 705381) and the APOE common polymorphism in 101 Polish patients with late-onset AD in response to treatment with AChEIs.

RESULTS

No significant differences were observed between carriers and non-carriers of the PON1 SNPs or the APOE common polymorphism in terms of treatment response. These results did not change after stratification of APOE status.

CONCLUSION

Our results suggest that both the investigated PON1 and APOE common SNPs do not influence treatment response to AChEIs in patients with AD.

Для цитирования: Klimkowicz-Mrowiec A, Marona M, Spisak K, Jagiella J, Wolkow P, Szczudlik A, Slowik A. Paraoxonase 1 gene polymorphisms do not influence the response to treatment in Alzheimer's disease.. Dementia and geriatric cognitive disorders. 2011. DOI: 10.1159/000330343.

Предметные рубрики MeSH

Подготовка и перевод публикации

Обработка статьи · этапы, ошибки и управление

Загрузка состояния…

История · было → стало

Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.