Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics · 1996
Oral involvement in chronic graft-versus-host disease after allogeneic bone marrow transplantation.
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Nakamura S, Hiroki A, Shinohara M, Gondo H, Ohyama Y, Mouri T, Sasaki M, Shirasuna K, Harada M, Niho Y
Аннотация
We examined 37 patients who had undergone an allogeneic bone marrow transplantation and compared their oral findings to their systemic involvement with chronic graft-versus-host disease. Among the clinical signs and symptoms in their oral region, only the presence of oral lichenoid lesions had a statistically significant relationship to the diagnosis of chronic graft-versus-host disease. The histologic findings in the labial salivary glands and buccal mucosa closely reflected the status of chronic graft-versus-host disease. Statistically, the presence of diffuse and periductal lymphocytic infiltration in labial salivary glands, subepithelial lymphocytic infiltration and epithelial changes in buccal mucosa also showed a significant relationship to the diagnosis of chronic graft-versus-host disease. The present study suggests that a systematic oral examination, especially pathologic examination of the labial salivary glands and buccal mucosa, is useful in evaluating the status of chronic graft-versus-host disease.