Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics · 2010
Up-regulation of EGF receptor and its ligands, AREG, EREG, and HB-EGF in oral lichen planus.
Сравнительное исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
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Kumagai Kenichi, Horikawa Tatsuya, Gotoh Akito, Yamane Shoji, Yamada Hiroyuki, Kobayashi Hiroshi, Hamada Yoshiki, Suzuki Satsuki, Suzuki Ryuji
Аннотация
OBJECTIVE: This study aimed to investigate the roles of the epidermal growth factor receptor (EGFR) family members and their ligands in oral lichen planus (OLP).
STUDY DESIGN: The expressions of 4 EGFR-like receptors and 6 EGF-like ligands were measured in OLP tissues from 10 patients and compared with the levels in normal oral mucosa (NOM) from 10 healthy donors.
RESULTS: Of the receptors, only EGFR mRNA and protein were more highly expressed in OLP compared with NOM tissues. Regarding the ligands, the mRNAs of amphiregulin (AREG), epiregulin (EREG), and heparin-binding EGF-like growth factor (HB-EGF) were more highly expressed in OLP compared with NOM tissues. These ligands were strongly expressed by infiltrating lamina propria lymphocytes as well as epithelial keratinocytes in OLP lesions, as shown by immunohistochemistry.
CONCLUSIONS: The enhanced EGFR expression on the keratinocytes in OLP lesions and the up-regulation of EGF-like ligands in keratinocytes and infiltrating mononuclear cells could contribute to the carcinogenesis and pathogenesis of OLP.
STUDY DESIGN: The expressions of 4 EGFR-like receptors and 6 EGF-like ligands were measured in OLP tissues from 10 patients and compared with the levels in normal oral mucosa (NOM) from 10 healthy donors.
RESULTS: Of the receptors, only EGFR mRNA and protein were more highly expressed in OLP compared with NOM tissues. Regarding the ligands, the mRNAs of amphiregulin (AREG), epiregulin (EREG), and heparin-binding EGF-like growth factor (HB-EGF) were more highly expressed in OLP compared with NOM tissues. These ligands were strongly expressed by infiltrating lamina propria lymphocytes as well as epithelial keratinocytes in OLP lesions, as shown by immunohistochemistry.
CONCLUSIONS: The enhanced EGFR expression on the keratinocytes in OLP lesions and the up-regulation of EGF-like ligands in keratinocytes and infiltrating mononuclear cells could contribute to the carcinogenesis and pathogenesis of OLP.
Предметные рубрики MeSH
AdultAgedAmphiregulinBetacellulinCD3 ComplexEGF Family of ProteinsEpidermal Growth FactorEpiregulinEpithelial CellsErbB ReceptorsFemaleGlycoproteinsHeparinHeparin-binding EGF-like Growth FactorHumansImmunohistochemistryIntercellular Signaling Peptides and ProteinsKeratinocytesLeukocytes, MononuclearLichen Planus, OralLymphocytesMaleMiddle AgedMouth MucosaPolymerase Chain ReactionErb-b2 Receptor Tyrosine KinasesReceptor, ErbB-3Receptor, ErbB-4Receptors, Cell SurfaceT-LymphocytesTransforming Growth Factor alphaUp-Regulation