The British journal of ophthalmology · 2014
Diclofenac versus fluorometholone after strabismus surgery in children.
Сравнительное исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Yang Hee Kyung, Han Sang Beom, Hwang Jeong-Min
Аннотация
AIMS: To compare the effects of topical diclofenac sodium with those of fluorometholone on intraocular pressure (IOP) and conjunctival inflammation after strabismus surgery.
METHODS: We retrospectively analysed 60 Korean children who underwent strabismus surgery for intermittent exotropia in an institutional referral centre. Patients received topical diclofenac 0.1% or fluorometholone 0.1% after surgery for up to 4 weeks. IOP, patient discomfort, conjunctival inflammation and conjunctival injection were evaluated at 1, 2, 3 and 4 weeks after surgery.
RESULTS: In the fluorometholone group, 23% showed an increase of ≥10 mm Hg compared to the baseline IOP within 4 weeks of surgery. The fluorometholone group showed a significant change in IOP compared to baseline (p<0.001) at all follow-up time points, whereas the diclofenac group showed no significant increase in IOP. An increased risk of IOP elevation of ≥10 mm Hg was observed after fluorometholone use in patients under 7 years of age. There was no significant difference in patient discomfort, conjunctival inflammation or conjunctival injection between the two groups. Conjunctival injection was more pronounced with muscle resection than with recession at 1 month after surgery.
CONCLUSIONS: Postoperative topical diclofenac is an excellent substitute for steroids, particularly in young children under 7 years of age.
METHODS: We retrospectively analysed 60 Korean children who underwent strabismus surgery for intermittent exotropia in an institutional referral centre. Patients received topical diclofenac 0.1% or fluorometholone 0.1% after surgery for up to 4 weeks. IOP, patient discomfort, conjunctival inflammation and conjunctival injection were evaluated at 1, 2, 3 and 4 weeks after surgery.
RESULTS: In the fluorometholone group, 23% showed an increase of ≥10 mm Hg compared to the baseline IOP within 4 weeks of surgery. The fluorometholone group showed a significant change in IOP compared to baseline (p<0.001) at all follow-up time points, whereas the diclofenac group showed no significant increase in IOP. An increased risk of IOP elevation of ≥10 mm Hg was observed after fluorometholone use in patients under 7 years of age. There was no significant difference in patient discomfort, conjunctival inflammation or conjunctival injection between the two groups. Conjunctival injection was more pronounced with muscle resection than with recession at 1 month after surgery.
CONCLUSIONS: Postoperative topical diclofenac is an excellent substitute for steroids, particularly in young children under 7 years of age.
Предметные рубрики MeSH
Administration, TopicalAnti-Inflammatory Agents, Non-SteroidalChildChild, PreschoolConjunctivitisDiclofenacExotropiaFemaleFluorometholoneGlucocorticoidsHumansIntraocular PressureMaleOculomotor MusclesOphthalmic SolutionsOphthalmologic Surgical ProceduresPostoperative CareRetrospective StudiesTonometry, Ocular