Медицинская библиотека · International journal of public health · 2025

Phenotypic Variation in Disease Severity Among Hospitalized Pediatric Patients With COVID-19: Assessing the Impact of COVID-19 in the EPICO Study.

Sossa-Alarcón María Camila, Gutiérrez Mónica Paola, Becerra Natalia, Ortegon Luz Yessenia, David María Camila, Vanegas Melisa Naranjo, Friedrich Gabriela, Vásquez-Hoyos Pablo, Mesa-Rubio María Lucía, Navarro-Ramirez Luis Miguel, Moreno-Lopez Sergio, Baquero Olga Lucía, Mejía Luz Marina, Piñeros Juan Gabriel, Restrepo-Gualteros Sonia, Álvarez-Moreno Carlos, Díaz-Díaz Alejandro, Gutierrez-Tobar Iván, Mesa Andrés Camilo, Bachiller Tuta William Ricardo, Galvis Diaz Clara Esperanza, Africano Martha, Nieto José Manuel, Pérez Camacho Paola Marsela, Beltrán-Arroyave Claudia, Vivas Trochez Rosalba, Gastesi Irati, Moraleda Cinta, Tagarro García Alfredo, Herrero Blanca, Calleja Lourdes, Grasa Carlos, Rodriguez Paula, Melendo Susana, Soriano-Arandes Antoni, Gómez Pastrana Irene, García García Sonsoles, Fumado Victoria, Ramírez Varela Andrea

СтатьяМногоцентровое исследованиеПеревод пока не подготовлен

Аннотация

OBJECTIVE

To characterize the clinical phenotypes of SARS-CoV-2 infection in hospitalized children as part of the EPICO multicenter cohort study.

METHODS

We included hospitalized children with confirmed SARS-CoV-2 infection from Colombian and Spanish institutions to assess disease evolution and outcomes. Cluster analysis was performed to identify clinical phenotypes.

RESULTS

A total of 2318 patients were included (55% male, 36% infants). Five phenotype clusters emerged: Cluster 1 (26.5%): infants without comorbidities, low PICU admissions and mortality; Cluster 2 (18.5%): respiratory comorbidities, high microorganism co-detection and mortality; Cluster 3 (11.5%): fever, gastrointestinal symptoms, high PICU admissions; Cluster 4 (32%): mild unspecific symptoms, low mortality; Cluster 5 (11.3%): adolescents without comorbidities, low co-detection and hospitalization rates. Findings were consistent across both countries.

CONCLUSION

Identifying clinical phenotypes of SARS-CoV-2 in children may improve risk stratification and guide future management strategies.

Для цитирования: Sossa-Alarcón María Camila, Gutiérrez Mónica Paola, Becerra Natalia, Ortegon Luz Yessenia, David María Camila, Vanegas Melisa Naranjo, Friedrich Gabriela, Vásquez-Hoyos Pablo, Mesa-Rubio María Lucía, Navarro-Ramirez Luis Miguel, Moreno-Lopez Sergio, Baquero Olga Lucía, Mejía Luz Marina, Piñeros Juan Gabriel, Restrepo-Gualteros Sonia, Álvarez-Moreno Carlos, Díaz-Díaz Alejandro, Gutierrez-Tobar Iván, Mesa Andrés Camilo, Bachiller Tuta William Ricardo, Galvis Diaz Clara Esperanza, Africano Martha, Nieto José Manuel, Pérez Camacho Paola Marsela, Beltrán-Arroyave Claudia, Vivas Trochez Rosalba, Gastesi Irati, Moraleda Cinta, Tagarro García Alfredo, Herrero Blanca, Calleja Lourdes, Grasa Carlos, Rodriguez Paula, Melendo Susana, Soriano-Arandes Antoni, Gómez Pastrana Irene, García García Sonsoles, Fumado Victoria, Ramírez Varela Andrea. Phenotypic Variation in Disease Severity Among Hospitalized Pediatric Patients With COVID-19: Assessing the Impact of COVID-19 in the EPICO Study.. International journal of public health. 2025. DOI: 10.3389/ijph.2025.1607246.

Предметные рубрики MeSH

Humans COVID-19 Male Female Infant Child Child, Preschool Severity of Illness Index Hospitalization Adolescent Phenotype Colombia SARS-CoV-2 Spain Comorbidity Cluster Analysis Cohort Studies

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