Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko · 2018
[Non-contrast ASL perfusion in preoperative diagnosis of supratentorial gliomas].
СтатьяНазвание и аннотация: Оригинал на русском
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Batalov A I, Zakharova N E, Pogosbekyan E L, Fadeeva L M, Goryaynov S A, Baev A A, Shul'ts E I, Chelushkin D M, Potapov A A, Pronin I N
Аннотация
The purpose of this study was to investigate the potential of pseudocontinuous arterial spin labeling perfusion (pCASL) in assessing the degree of malignancy of brain gliomas at the preoperative stage. MATERIAL AND METHODS: The study included 126 patients aged 12-75 years with supratentorial gliomas of different malignancy (35 low-grade gliomas and 91 high-grade gliomas). The maximum tumor blood flow (TBF) was measured, and the normalized tumor blood flow (nTBF) was calculated relative to the intact semiovale white matter of the contralateral hemisphere. The TBF and nTBF indicators differed significantly between low-grade and high-grade glioma groups (p<0.001). When using TBF and nTBF in the differential diagnosis of low-grade and high-grade gliomas, the area under the ROC curve was 0.96 in both cases. Our findings suggest that 3D pCASL perfusion is an effective technique for preoperative differential diagnosis of low-grade and high-grade gliomas. The study was supported by the Russian Foundation for Basic Research (grant #18-315-00384).