Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2011
Examination of 11C-methionine metabolism by the standardized uptake value in the normal brain of children.
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Nagata Takashi, Tsuyuguchi Naohiro, Uda Takehiro, Terakawa Yuzo, Takami Toshihiro, Ohata Kenji
Аннотация
UNLABELLED: The aim of this study was to determine the uptake of L-[methyl-(11)C]-methionine ((11)C-MET) in the normal brain of patients younger than 20 y, to facilitate more accurate diagnoses in young patients.
METHODS: Eighty-two patients were categorized into 4 groups according to their age. They underwent (11)C-MET PET, and a standardized uptake value (SUV) was determined for different brain regions including the frontal lobe, parietal lobe, cerebellum, and brain stem.
RESULTS: Compared with all other parts of the brain, the cerebellum had the highest SUV. A tendency for a positive relationship between SUV and age was found in all regions, and a significant relationship with SUV was found in the frontal lobe and cerebellum.
CONCLUSION: The character of SUV in the normal brains of children is different from that of adults, and these normal SUV data will play an important role as a critical reference value.
METHODS: Eighty-two patients were categorized into 4 groups according to their age. They underwent (11)C-MET PET, and a standardized uptake value (SUV) was determined for different brain regions including the frontal lobe, parietal lobe, cerebellum, and brain stem.
RESULTS: Compared with all other parts of the brain, the cerebellum had the highest SUV. A tendency for a positive relationship between SUV and age was found in all regions, and a significant relationship with SUV was found in the frontal lobe and cerebellum.
CONCLUSION: The character of SUV in the normal brains of children is different from that of adults, and these normal SUV data will play an important role as a critical reference value.