Journal of translational medicine · 2012
Safety and feasibility of countering neurological impairment by intravenous administration of autologous cord blood in cerebral palsy.
Клиническое исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Lee Young-Ho, Choi Kyung Vin, Moon Jin Hwa, Jun Hyun-Joo, Kang Hye-Ryeong, Oh Se-In, Kim Hyung Sun, Um Jang Soo, Kim Mi Jung, Choi Yun Young, Lee Young-Jun, Kim Hee-Jin, Lee Jong-Hwa, Son Su Min, Choi Soo-Jin, Oh Wonil, Yang Yoon-Sun
Аннотация
BACKGROUNDS: We conducted a pilot study of the infusion of intravenous autologous cord blood (CB) in children with cerebral palsy (CP) to assess the safety and feasibility of the procedure as well as its potential efficacy in countering neurological impairment.
METHODS: Patients diagnosed with CP were enrolled in this study if their parents had elected to bank their CB at birth. Cryopreserved CB units were thawed and infused intravenously over 10~20 minutes. We assessed potential efficacy over 6 months by brain magnetic resonance imaging (MRI)-diffusion tensor imaging (DTI), brain perfusion single-photon emission computed tomography (SPECT), and various evaluation tools for motor and cognitive functions.
RESULTS: Twenty patients received autologous CB infusion and were evaluated. The types of CP were as follows: 11 quadriplegics, 6 hemiplegics, and 3 diplegics. Infusion was generally well-tolerated, although 5 patients experienced temporary nausea, hemoglobinuria, or urticaria during intravenous infusion. Diverse neurological domains improved in 5 patients (25%) as assessed with developmental evaluation tools as well as by fractional anisotropy values in brain MRI-DTI. The neurologic improvement occurred significantly in patients with diplegia or hemiplegia rather than quadriplegia.
CONCLUSIONS: Autologous CB infusion is safe and feasible, and has yielded potential benefits in children with CP.
METHODS: Patients diagnosed with CP were enrolled in this study if their parents had elected to bank their CB at birth. Cryopreserved CB units were thawed and infused intravenously over 10~20 minutes. We assessed potential efficacy over 6 months by brain magnetic resonance imaging (MRI)-diffusion tensor imaging (DTI), brain perfusion single-photon emission computed tomography (SPECT), and various evaluation tools for motor and cognitive functions.
RESULTS: Twenty patients received autologous CB infusion and were evaluated. The types of CP were as follows: 11 quadriplegics, 6 hemiplegics, and 3 diplegics. Infusion was generally well-tolerated, although 5 patients experienced temporary nausea, hemoglobinuria, or urticaria during intravenous infusion. Diverse neurological domains improved in 5 patients (25%) as assessed with developmental evaluation tools as well as by fractional anisotropy values in brain MRI-DTI. The neurologic improvement occurred significantly in patients with diplegia or hemiplegia rather than quadriplegia.
CONCLUSIONS: Autologous CB infusion is safe and feasible, and has yielded potential benefits in children with CP.
Предметные рубрики MeSH
Blood TransfusionBrainCerebral PalsyChildChild, PreschoolCognition DisordersDiffusion Tensor ImagingFeasibility StudiesFemaleFetal BloodHumansInfusions, IntravenousMagnetic Resonance ImagingMaleNeurologic ExaminationPilot ProjectsPsychomotor DisordersRadiographyTransfusion ReactionTransplantation, Autologous