Journal of psychiatric research · 2026
A systematic review and meta-analysis of anxiety and depression in children and adolescents with inflammatory bowel disease: Prevalence and association.
СтатьяСистематический обзорМетаанализНазвание и аннотация: Перевод пока не подготовлен
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Xu Tingting, Chen Yanhong, Shen Qiqi, Dai Sichao, Yan Haohao, Ren Jianjuan
Аннотация
BACKGROUND: Anxiety and depression are prevalent comorbidities in patients with inflammatory bowel disease (IBD). However, their prevalence and impact in children and adolescents with IBD remain poorly defined. This meta-analysis aimed (i) to estimate the prevalence of anxiety and depression in this population and (ii) to explore the association between these psychological issues and IBD.
METHODS: A thorough search of Embase, Web of Science, and PubMed from inception through February 1, 2025, was conducted. Two authors independently extracted data and assessed study quality. Pooled prevalence estimates, odds ratios (ORs), and hazard ratios (HRs) were calculated using a random-effects model. Subgroup and sensitivity analyses were performed to examine sources of heterogeneity and assess result robustness.
RESULTS: The meta-analysis included 48 studies with 189,032 children and adolescents with IBD. Pooled prevalence estimates were as follows: anxiety symptoms (12%; 95% confidence interval [CI]: 7%-17%; k [number of studies] = 14; n [number of subjects] = 1574); anxiety disorders (9%; 95% CI: 5%-14%; k = 6; n = 168,378); depressive symptoms (15%; 95% CI: 11%-19%; k = 35; n = 4426); and depressive disorder (8%; 95% CI: 5%-11%; k = 7; n = 168,475). Pooled HRs indicated a significantly higher risk of developing anxiety and depressive disorders in this population, with HRs of 1.95 and 1.65, respectively.
CONCLUSIONS: Children and adolescents with IBD face a substantial burden of anxiety and depression. Routine mental health screening is essential for early intervention and comprehensive management of these comorbidities.
METHODS: A thorough search of Embase, Web of Science, and PubMed from inception through February 1, 2025, was conducted. Two authors independently extracted data and assessed study quality. Pooled prevalence estimates, odds ratios (ORs), and hazard ratios (HRs) were calculated using a random-effects model. Subgroup and sensitivity analyses were performed to examine sources of heterogeneity and assess result robustness.
RESULTS: The meta-analysis included 48 studies with 189,032 children and adolescents with IBD. Pooled prevalence estimates were as follows: anxiety symptoms (12%; 95% confidence interval [CI]: 7%-17%; k [number of studies] = 14; n [number of subjects] = 1574); anxiety disorders (9%; 95% CI: 5%-14%; k = 6; n = 168,378); depressive symptoms (15%; 95% CI: 11%-19%; k = 35; n = 4426); and depressive disorder (8%; 95% CI: 5%-11%; k = 7; n = 168,475). Pooled HRs indicated a significantly higher risk of developing anxiety and depressive disorders in this population, with HRs of 1.95 and 1.65, respectively.
CONCLUSIONS: Children and adolescents with IBD face a substantial burden of anxiety and depression. Routine mental health screening is essential for early intervention and comprehensive management of these comorbidities.