Pediatric obesity · 2019
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СтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод пока не подготовлен
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Petimar Joshua, Rifas-Shiman Sheryl L, Hivert Marie-France, Fleisch Abby F, Tiemeier Henning, Oken Emily
Аннотация
OBJECTIVE:: To examine associations of hair cortisol concentration (HCC) in mid-childhood and change in HCC from mid-childhood to early adolescence (ΔHCC) with early adolescent adiposity and cardiometabolic biomarker measures.
METHODS:: In Project Viva, a pre-birth cohort of mothers and children, we measured HCC in 599 white children in mid-childhood and in 426 of these participants in early adolescence. We used multivariable linear regression to examine associations of mid-childhood HCC and ΔHCC with BMI-for-age-and-sex z-score, waist circumference, waist-height ratio, dual X-ray absorptiometry total and trunk fat mass, a metabolic risk z-score, adiponectin, HOMA-IR, high-density lipoprotein, C-reactive protein, interleukin-6, leptin, and systolic blood pressure.
RESULTS:: Over a mean (SD) follow-up of 5.2 (0.8) years, we did not find associations of mid-childhood HCC with BMI-for-age-and-sex z-score (β=0.00 per 1-interquartile range of HCC, 95% confidence interval [CI]: −0.08, 0.07), waist circumference (β=−0.04cm, 95% CI: −0.83, 0.74), metabolic risk z-score (β=0.04, 95% CI: −0.03, 0.11), or other cardiometabolic measures except for an increase in log-transformed HOMA-IR (β=0.10, 95% CI: 0.04, 0.17). ΔHCC was not associated with any outcome measures.
CONCLUSIONS:: We found that mid-childhood HCC was not associated with early adolescent adiposity or cardiometabolic biomarkers except for a slight increase in HOMA-IR.
METHODS:: In Project Viva, a pre-birth cohort of mothers and children, we measured HCC in 599 white children in mid-childhood and in 426 of these participants in early adolescence. We used multivariable linear regression to examine associations of mid-childhood HCC and ΔHCC with BMI-for-age-and-sex z-score, waist circumference, waist-height ratio, dual X-ray absorptiometry total and trunk fat mass, a metabolic risk z-score, adiponectin, HOMA-IR, high-density lipoprotein, C-reactive protein, interleukin-6, leptin, and systolic blood pressure.
RESULTS:: Over a mean (SD) follow-up of 5.2 (0.8) years, we did not find associations of mid-childhood HCC with BMI-for-age-and-sex z-score (β=0.00 per 1-interquartile range of HCC, 95% confidence interval [CI]: −0.08, 0.07), waist circumference (β=−0.04cm, 95% CI: −0.83, 0.74), metabolic risk z-score (β=0.04, 95% CI: −0.03, 0.11), or other cardiometabolic measures except for an increase in log-transformed HOMA-IR (β=0.10, 95% CI: 0.04, 0.17). ΔHCC was not associated with any outcome measures.
CONCLUSIONS:: We found that mid-childhood HCC was not associated with early adolescent adiposity or cardiometabolic biomarkers except for a slight increase in HOMA-IR.