The American journal of clinical nutrition · 2026
Relationship of tea consumption and its circulating biomarkers with longitudinal bone mineral changes: a prospective cohort study with repeated measurements.
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He Silei, Yan Yan, Zhou Sijia, Hong Zhen, Huang Shuyang, Liu Yi, Tang Enhui, Xi Yue, Chen Yuming, Zhang Zheqing
Аннотация
BACKGROUND: Tea is a dietary source of flavan-3-ols, which may influence bone health, but prospective evidence linking tea intake and its circulating biomarkers with longitudinal bone mineral status remains limited.
OBJECTIVES: To examine associations of tea consumption and its serum biomarkers with bone mineral status in Guangzhou Nutrition and Health Study.
METHODS: In 1708 participants, whole-body, total hip, lumbar spine, and femoral neck bone mineral density (BMD) and bone mineral content (BMC) were measured using dual-energy X-ray absorptiometry at 4 repeated visits during a 13-y follow-up period. Baseline serum flavan-3-ols, including epicatechin, epigallocatechin gallate (EGCG), epicatechin gallate (ECG), epigallocatechin, and catechin, were quantified using ultra-high-performance liquid chromatography-tandem mass spectrometry. Tea consumption was categorized as non-, low-, moderate-, or high-frequency. Multivariable linear mixed-effects models, including exposure × visit interactions, were used to evaluate visit-averaged bone mineral measures and longitudinal trajectories.
RESULTS: Among 1708 participants, significant tea consumption group × visit interactions were observed for whole-body, lumbar spine, and femoral neck BMD and whole-body BMC (P-interaction ranged from <0.001 to 0.022). Moderate-frequency tea drinkers generally had the highest visit-averaged adjusted marginal mean Z-scores, including 0.107 (95% CI: 0.025, 0.190) for whole-body BMD, 0.090 (0.012, 0.168) for lumbar spine BMD, and 0.108 (0.029, 0.187) for femoral neck BMD (P-diff ranged from <0.001 to 0.017). In analyses of serum tea biomarkers, higher biomarker categories were generally associated with more favorable bone mineral measures; however, the associations were not consistently linear, and several biomarkers showed nonmonotonic patterns. Visit-averaged differences were most extensive across ECG and EGCG categories.
CONCLUSIONS: Moderate-frequency tea consumption and higher categories of selected circulating tea biomarkers were associated with more favorable bone mineral status.
OBJECTIVES: To examine associations of tea consumption and its serum biomarkers with bone mineral status in Guangzhou Nutrition and Health Study.
METHODS: In 1708 participants, whole-body, total hip, lumbar spine, and femoral neck bone mineral density (BMD) and bone mineral content (BMC) were measured using dual-energy X-ray absorptiometry at 4 repeated visits during a 13-y follow-up period. Baseline serum flavan-3-ols, including epicatechin, epigallocatechin gallate (EGCG), epicatechin gallate (ECG), epigallocatechin, and catechin, were quantified using ultra-high-performance liquid chromatography-tandem mass spectrometry. Tea consumption was categorized as non-, low-, moderate-, or high-frequency. Multivariable linear mixed-effects models, including exposure × visit interactions, were used to evaluate visit-averaged bone mineral measures and longitudinal trajectories.
RESULTS: Among 1708 participants, significant tea consumption group × visit interactions were observed for whole-body, lumbar spine, and femoral neck BMD and whole-body BMC (P-interaction ranged from <0.001 to 0.022). Moderate-frequency tea drinkers generally had the highest visit-averaged adjusted marginal mean Z-scores, including 0.107 (95% CI: 0.025, 0.190) for whole-body BMD, 0.090 (0.012, 0.168) for lumbar spine BMD, and 0.108 (0.029, 0.187) for femoral neck BMD (P-diff ranged from <0.001 to 0.017). In analyses of serum tea biomarkers, higher biomarker categories were generally associated with more favorable bone mineral measures; however, the associations were not consistently linear, and several biomarkers showed nonmonotonic patterns. Visit-averaged differences were most extensive across ECG and EGCG categories.
CONCLUSIONS: Moderate-frequency tea consumption and higher categories of selected circulating tea biomarkers were associated with more favorable bone mineral status.