Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium.
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Kong Xiang-Zhen, Boedhoe Premika S W, Abe Yoshinari, Alonso Pino, Ameis Stephanie H, Arnold Paul D, Assogna Francesca, Baker Justin T, Batistuzzo Marcelo C, Benedetti Francesco, Beucke Jan C, Bollettini Irene, Bose Anushree, Brem Silvia, Brennan Brian P, Buitelaar Jan, Calvo Rosa, Cheng Yuqi, Cho Kang Ik K, Dallaspezia Sara, Denys Damiaan, Ely Benjamin A, Feusner Jamie, Fitzgerald Kate D, Fouche Jean-Paul, Fridgeirsson Egill A, Glahn David C, Gruner Patricia, Gürsel Deniz A, Hauser Tobias U, Hirano Yoshiyuki, Hoexter Marcelo Q, Hu Hao, Huyser Chaim, James Anthony, Jaspers-Fayer Fern, Kathmann Norbert, Kaufmann Christian, Koch Kathrin, Kuno Masaru, Kvale Gerd, Kwon Jun Soo, Lazaro Luisa, Liu Yanni, Lochner Christine, Marques Paulo, Marsh Rachel, Martínez-Zalacaín Ignacio, Mataix-Cols David, Medland Sarah E, Menchón José M, Minuzzi Luciano, Moreira Pedro S, Morer Astrid, Morgado Pedro, Nakagawa Akiko, Nakamae Takashi, Nakao Tomohiro, Narayanaswamy Janardhanan C, Nurmi Erika L, O'Neill Joseph, Pariente Jose C, Perriello Chris, Piacentini John, Piras Fabrizio, Piras Federica, Pittenger Christopher, Reddy Y C Janardhan, Rus-Oswald Oana Georgiana, Sakai Yuki, Sato Joao R, Schmaal Lianne, Simpson H Blair, Soreni Noam, Soriano-Mas Carles, Spalletta Gianfranco, Stern Emily R, Stevens Michael C, Stewart S Evelyn, Szeszko Philip R, Tolin David F, Tsuchiyagaito Aki, van Rooij Daan, van Wingen Guido A, Venkatasubramanian Ganesan, Wang Zhen, Yun Je-Yeon, ENIGMA OCD Working Group, Thompson Paul M, Stein Dan J, van den Heuvel Odile A, Francks Clyde
Аннотация
METHODS: We studied a collection of 16 pediatric datasets (501 patients with OCD and 439 healthy control subjects), as well as 30 adult datasets (1777 patients and 1654 control subjects) from the OCD Working Group within the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Consortium. Asymmetries of the volumes of subcortical structures, and of measures of regional cortical thickness and surface areas, were assessed based on T1-weighted magnetic resonance imaging scans, using harmonized image analysis and quality control protocols. We investigated possible alterations of brain asymmetry in patients with OCD. We also explored potential associations of asymmetry with specific aspects of the disorder and medication status.
RESULTS: In the pediatric datasets, the largest case-control differences were observed for volume asymmetry of the thalamus (more leftward; Cohen's d = 0.19) and the pallidum (less leftward; d = -0.21). Additional analyses suggested putative links between these asymmetry patterns and medication status, OCD severity, or anxiety and depression comorbidities. No significant case-control differences were found in the adult datasets.
CONCLUSIONS: The results suggest subtle changes of the average asymmetry of subcortical structures in pediatric OCD, which are not detectable in adults with the disorder. These findings may reflect altered neurodevelopmental processes in OCD.