Natural product research · 2019
Dimeric glycosylated flavan-3-ol and antimicrobial in vitro evaluation of Trichilia catigua extracts.
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Ritter Mariane Roberta, Tempesta de Oliveira Marcelo, Makimori Regina Yasuko, Sereia Ana Luiza, Simionato Ane Stefano, Chierrito Danielly, Galdino Andrade Filho, Gonçalves de Oliveira Admilton, Brentan da Silva Denise, Novello Claudio Roberto, Cristina de Medeiros Daniela, Benedito Prado Dias Filho, João Carlos Palazzo de Mello
Аннотация
Trichilia catigua is a tree known as "catuaba", widely distributed in Brazil. Studies carried out with T. catigua barks suggest that plant has antidepressant, antidiabetic, antimicrobial, antioxidant, antiviral, and preventive against brain damage. The aim of this work was to isolate and characterise compounds from the semipurified fraction of T. catigua barks, and to conduct microbiological screening against bacteria and fungi. The crude extract (CE) of "catuaba" was produced by turbo extraction with acetone-water, and later, partitioned to yield ethyl-acetate (EAF) and aqueous (AqF) fractions. From AqF the new catechin-3-O-α-L-rhamnoside-(4α→8)-epicatechin was isolated, identified, and described here for the first time. Regarding antimicrobial activity, the extracts presented impressive results, mainly for Vancomycin Resistant Enterococcus faecium (VREfm) with MIC of 156.5 μg/mL. The results suggest that extract of T. catigua could potentially be used as an adjuvant to treatment and is a promising candidate for the development of new antimicrobial drugs.