Consortium profile: the methylation, imaging and NeuroDevelopment (MIND) consortium.
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Schuurmans Isabel K, Mulder Rosa H, Baltramonaityte Vilte, Lahtinen Alexandra, Qiuyu Fan, Rothmann Leonardo Melo, Staginnus Marlene, Tuulari Jetro J, Burt S Alexandra, Buss Claudia, Craig Jeffrey M, Donald Kirsten A, Eriksson Johan G, Felix Janine F, Freeman Tom P, Grassi-Oliveira Rodrigo, Huels Anke, Hyde Luke W, Jones Scott A, Karlsson Hasse, Karlsson Linnea, Koen Nastassja, Lawn Will, Mitchell Colter, Monk Christopher S, Mooney Michael A, Muetzel Ryan, Nigg Joel T, Belangero Síntia Iole Nogueira, Notterman Daniel, Ong Yi Ying, O'Connor Tom, O'Donnell Kieran J, Pan Pedro Mario, Paunio Tiina, Ryabinin Peter, Saffery Richard, Salum Giovanni A, Seal Marc, Silk Tim J, Stein Dan J, Tan Ai Peng, Teh Ai Ling, Wang Dennis, Zar Heather, Walton Esther, Cecil Charlotte A M
Аннотация
Epigenetic processes, such as DNA methylation, show potential as biological markers and mechanisms underlying gene-environment interplay in the prediction of mental health and other brain-based phenotypes. However, little is known about how peripheral epigenetic patterns relate to individual differences in the brain itself. An increasingly popular approach to address this is by combining epigenetic and neuroimaging data; yet, research in this area is almost entirely comprised of cross-sectional studies in adults. To bridge this gap, we established the Methylation, Imaging and NeuroDevelopment (MIND) Consortium, which aims to bring a developmental focus to the emerging field of Neuroimaging Epigenetics by (i) promoting collaborative, adequately powered developmental research via multi-cohort analyses; (ii) increasing scientific rigor through the establishment of shared pipelines and open science practices; and (iii) advancing our understanding of DNA methylation-brain dynamics at different developmental periods (from birth to emerging adulthood), by leveraging data from prospective, longitudinal pediatric studies. MIND currently integrates 16 cohorts worldwide, comprising (repeated) measures of DNA methylation in peripheral tissues (blood, buccal cells, and saliva) and neuroimaging by magnetic resonance imaging across up to five time points over a period of up to 21 years (Npooled DNAm = 12,877; Npooled neuroimaging = 10,899; Npooled combined = 6074). By triangulating associations across multiple developmental time points and study types, we hope to generate new insights into the dynamic relationships between peripheral DNA methylation and the brain, and how these ultimately relate to neurodevelopmental and psychiatric phenotypes.