AIDS research and human retroviruses · 2010
Short communication: evaluation of the effect of enfuvirtide in 11 HIV-1 vertically infected pediatric patients outside clinical trials.
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Palladino C, Briz V, González-Tomé M I, León Leal J A, Navarro M L, de José M I, Ramos J T, Muñoz-Fernández Ma Angeles
Аннотация
The effect of enfuvirtide (ENF) in 11 HIV-1 heavily antiretroviral-experienced children and adolescents enrolled in the HIV-1 Paediatric Spanish cohort was further investigated. Patients who received ENF with novel drugs (etravirine, darunavir, and/or tipranavir) reached and maintained undetectable plasma HIV-1 RNA levels and showed immunological recovery within the first 3 months of therapy that was maintained during the follow-up. Viremia was not fully suppressed in patients who did not combine ENF with novel drugs but interestingly, immunological benefit was observed in half of these patients. Therefore, ENF showed a greater and more stable efficacy when administrated with novel drugs.
Предметные рубрики MeSH
AdolescentChildDarunavirDrug Resistance, Multiple, ViralDrug Therapy, CombinationEnfuvirtideHIV Envelope Protein gp41HIV Fusion InhibitorsHIV InfectionsHIV Protease InhibitorsHIV-1HumansInfectious Disease Transmission, VerticalNitrilesPeptide FragmentsPyridazinesPyridinesPyrimidinesPyronesSulfonamidesTime FactorsTreatment OutcomeYoung Adult