The Neighborhoods Study: Examining the social exposome in Alzheimer's disease and related dementias.
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George Grace C, Keller Sarah A, Abner Erin, Adar Sara, Alosco Michael L, Apostolova Liana G, Bakulski Kelly, Barnes Lisa L, Bateman James R, Batterman Stuart, Beach Thomas G, Bendlin Barbara B, Bennett David A, Betthauser Tobey J, Brewer James, Buckingham William, Carrión Carmen I, Chodosh Joshua, Craft Suzanne, Croff Raina, Fabio Anthony, Farias Sarah Tomaszewski, Feldman Eva L, Goldstein Felicia, Goutman Stephen A, Green-Harris Gina, Henderson Victor, Karikari Thomas K, Kofler Julia, Kucharska-Newton Anna, Lamar Melissa, Lanata Serggio, Lepping Rebecca J, Lingler Jennifer, Lockhart Samuel, Mahnken Jonathan, Marsh Karyn, Mathew Jomol, Mecca Adam P, Meyer Oanh, Miller Bruce, Morris Jill, Neugroschl Judith, O'Connor Maureen K, Paulson Henry, Perrin Richard J, Pettigrew Corinne, Pierce Aimee, Powell W Ryan, Pyarajan Saiju, Raji Cyrus A, Reiman Eric, Risacher Shannon, Rissman Robert, Espinosa Patricia Rodriguez, Sano Mary, Saykin Andrew J, Serrano Geidy E, Singh Vikas, Soldan Anja, Sultzer David, van Dyck Christopher H, Whitmer Rachel, Wisniewski Thomas, Woltjer Randall, Yu Menggang, Zhu Carolyn W, Kind Amy J H
Аннотация
METHODS: TNS uses innovative methods to determine lifetime addresses of living (n = ≈ 3116) and brain bank cohorts (n = ≈ 8637). Addresses are linked to time-concordant adverse social exposome using the Area Deprivation Index (ADI) and summarized over time. Brain health measures are provided by the National Alzheimer's Coordinating Center.
RESULTS: We highlight a general overview and methodology of TNS. Data collection is ongoing; however, preliminary findings indicate that the adverse social exposome is related to ADRD biomarkers, neuropathology, and cognitive function.
DISCUSSION: TNS is the largest study of adverse social exposome and ADRD, using the ADRC network to build robust scientific consortia. Its findings will inform ADRD interventions, precision medicine, and policy.
HIGHLIGHTS: The Neighborhoods Study (TNS) investigates adverse social exposome and brain health. TNS is a collaboration among 22 Alzheimer's Disease Research Centers. TNS will give insight on environmental and exposomal factors which may be modifiable. Participant lifetime addresses are linked to temporal adverse social exposome metrics. This study's findings will inform precision approaches to mitigate dementia risk.