Review Article: CD151 and TGF-β in Colon Cancer Metastasis: Flavonoids and Their Targeted Delivery Systems.

Colon cancer (CC) is the 3rd most prevalent cancer globally, following breast and lung cancer, with the second-highest mortality rate. Multiple risk factors contribute to CC, and metastasis is the primary cause of increased mortality among CC patients. Natural compounds have been investigated for their ability to concurrently influence various carcinogenic mechanisms by interfering with the expression or activity of their signaling targets. This review focuses on natural flavonoids such as quercetin, taxifolin, and rutin. We discuss how these bioactive compounds potentially mitigate metastasis and associated signaling pathways in colon cancer.