Boletin de la Asociacion Medica de Puerto Rico · 2011
Independent association of LDL-C and non HDL-C with acute coronary syndrome in a Hispanic population.
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Trinidad Rafael, Gómez José, García Mateo José, Magraner Miguel, Bredy Rafael
Аннотация
UNLABELLED: There is an identified relationship between increasing plasma cholesterol and the incidence of Acute Coronary Syndrome (ACS). The National Cholesterol Education Program Adult Treatment Panel identified low-density lipoprotein--cholesterol (LDL-C) as the first target of therapy and non high-density lipoprotein cholesterol (Non HDL-C) as the second target. However, in epidemiologic studies non-HDL is a superior predictor of cardiovascular risk compared with LDL-C. We don't know the independent association of non HDL-C and LDL-C in Hispanic population with ACS.
METHODS: We evaluated patients with acute coronary syndrome admitted to Damas Hospital CCU, ICU & Telemetry Unit during a five months period and previous criteria of uncontrolled lipid levels. We compared the independent association of uncontrolled lipids levels with subsequent acute coronary syndrome.
RESULTS: Of 26 patients with ACS, 58% had independently association with non HDL-C elevation and 42% with LDL-C elevation. Regardless the categorization of the cardiovascular event, 6 of the 8 female patients had predominantly elevated blood levels of LDL as an independent factor. On the other hand, 15 of 18 male patients had Non-HDL elevated blood levels.
DISCUSSION: The association of ACS with independent lipid levels of LDL and non-HDL seems to be equivalent in our population. Interestingly there seems to be a female predominance in elevated LDL levels and a male predominance elevated blood levels of Non-HDL associated with cardiovascular events.
METHODS: We evaluated patients with acute coronary syndrome admitted to Damas Hospital CCU, ICU & Telemetry Unit during a five months period and previous criteria of uncontrolled lipid levels. We compared the independent association of uncontrolled lipids levels with subsequent acute coronary syndrome.
RESULTS: Of 26 patients with ACS, 58% had independently association with non HDL-C elevation and 42% with LDL-C elevation. Regardless the categorization of the cardiovascular event, 6 of the 8 female patients had predominantly elevated blood levels of LDL as an independent factor. On the other hand, 15 of 18 male patients had Non-HDL elevated blood levels.
DISCUSSION: The association of ACS with independent lipid levels of LDL and non-HDL seems to be equivalent in our population. Interestingly there seems to be a female predominance in elevated LDL levels and a male predominance elevated blood levels of Non-HDL associated with cardiovascular events.