Soft neural interface with color adjusted PDMS encapsulation layer for spinal cord stimulation.

BACKGROUND

Spinal cord stimulation (SCS) plays a crucial role in treating various neurological diseases. Utilizing soft spinal cord electrodes in SCS allows for a better fit with the physiological structure of the spinal cord and reduces tissue damage. Polydimethylsiloxane (PDMS) has emerged as an ideal material for soft bioelectronics. However, micromachining soft PDMS bioelectronics devices with low thermal effects and high uniformity remains challenging.

NEW METHOD: Here, we demonstrated a fully laser-micromachined soft neural interface for SCS. The native and color adjusted PDMS with variable absorbance characteristics were investigated in laser processing. In addition, we systematically evaluated the impact of electrode sizes on the electrochemical performance of neural interface. By fitting the equivalent circuit model, the electrochemical process of neural interface was revealed and the performance of the electrode was evaluated. The biocompatibility of color adjusted PDMS was confirmed by cytotoxicity assays. Finally, we validated the neural interface in mice.

RESULTS

Color adjusted PDMS has good biocompatibility and can significantly reduce the damage caused by thermal effects, enhancing the electrochemical performance of bioelectronic devices. The soft neural interface with color adjusted PDMS encapsulation layer can activate the motor function safely.

COMPARISON WITH EXISTING

METHODS

The fully laser-micromachined soft neural interface was proposed for the first time. Compared with existing methods, this method showed low thermal effects, high uniformity, and could be easily scaled up.

CONCLUSIONS

The fully laser-micromachined soft neural interface device with color adjusted PDMS encapsulation layer shows great promise for applications in SCS.