Journal of occupational and environmental medicine · 2026
The Effect of Employment Status and Work Schedule on All-cause Dementia: A Longitudinal Analysis From the Australian Longitudinal Study on Women's Health.
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Khaing Kay, Dolja-Gore Xenia, Nair Balakrishnan R, Byles Julie, Attia John
Аннотация
OBJECTIVES: This study assessed the effect of employment status and work schedule on all-cause dementia.
METHODS: A total of 10,349 participants from the Australian Longitudinal Study on Women's Health (mean age 47 years) were recruited. Work information was gathered using a self-reported questionnaire. Dementia was defined as per International Classification of Disease-10 codes. The Fine-Gray subdistribution hazard model was used for analysis.
RESULTS: Unemployment and rotating shift work increased the risk of all-cause dementia (HR, 1.77; 95% CI, 1.18-2.64 and HR, 1.89; 95% CI, 1.23-2.91, respectively). No statistically significant association was observed for only night shift work or volunteering. There was no dose-response relationship between years of shift work and risk of dementia.
CONCLUSION: Unemployment and rotating shift work were associated with increased risk of all-cause dementia, suggesting these may be potential modifiable risk factors for dementia.
METHODS: A total of 10,349 participants from the Australian Longitudinal Study on Women's Health (mean age 47 years) were recruited. Work information was gathered using a self-reported questionnaire. Dementia was defined as per International Classification of Disease-10 codes. The Fine-Gray subdistribution hazard model was used for analysis.
RESULTS: Unemployment and rotating shift work increased the risk of all-cause dementia (HR, 1.77; 95% CI, 1.18-2.64 and HR, 1.89; 95% CI, 1.23-2.91, respectively). No statistically significant association was observed for only night shift work or volunteering. There was no dose-response relationship between years of shift work and risk of dementia.
CONCLUSION: Unemployment and rotating shift work were associated with increased risk of all-cause dementia, suggesting these may be potential modifiable risk factors for dementia.