[Reactive transformation of human urinary smooth muscular tissue in some diseases (structural-metabolic aspects of organization)].

Smooth muscular tissue (SMT) of human urinary system was studied at different levels (renal pelvis, proximal and distal parts of the ureter) in health and some urological diseases (vesicoureteral reflux, ureteral obstruction). The method of target cell dissociation was used. The volume of myocytes, nuclei, nuclear-cytoplasmic correlation were calculated. Content of DNA and cytoplasmic protein was studied cytospectrophotometrically. Electron-microscopic study was also made. Three types of myocytes with different structural-metabolic parameters were detected. There were significant differences in mean volumes of myocytes, cytophotometric indices of SMT in different parts of the urinary tracts related to the pattern of these zones functioning. A comparative analysis of intact and affected SMT of the distal ureter demonstrated changes in the structure of leiomyocytes population, optic density of cytoplasmic protein and proliferative activity of myocytes which correlated depending on the kind and change of functional load.