Brain stimulation · 2021
Transcranial brain atlas for school-aged children and adolescents.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Zhang Zong, Li Zheng, Xiao Xiang, Zhao Yang, Zuo Xi-Nian, Zhu Chaozhe
Аннотация
BACKGROUND: Both fNIRS optodes and TMS coils are placed on the scalp, while the targeted brain activities are inside the brain. An accurate cranio-cortical correspondence is crucial to the precise localization of the cortical area under imaging or stimulation (i.e. transcranial locating), as well as guiding the placement of optodes/coils (i.e. transcranial targeting). However, the existing normative cranio-cortical correspondence data used as transcranial references are predominantly derived from the adult population, and whether and how correspondence changes during childhood and adolescence is currently unclear.
OBJECTIVE: This study aimed to build the age-specific cranio-cortical correspondences for school-aged children and adolescents and investigate its differences to adults.
METHODS: Age-specific transcranial brain atlases (TBAs) were built with age groups: 6-8, 8-10, 10-12, 12-14, 14-16, and 16-18 years. We compared the performance in both transcranial locating and targeting when using the age-appropriate TBA versus the adult TBA (derived from adult population) for children.
RESULTS: These atlases provide age-specific probabilistic cranio-cortical correspondence at a high resolution (average scalp spacing of 2.8 mm). Significant differences in cranio-cortical correspondence between children/adolescents and adults were found: the younger the child, the greater the differences. For children (aged 6-12 years), locating and targeting errors when using the adult TBA reached 10 mm or more in the bilateral temporal lobe and frontal lobe. In contrast, the age-matched TBA reduced these errors to 4-5 mm, an approximately 50% reduction in error.
CONCLUSION: Our work provides an accurate and effective anatomical reference for studies in children and adolescents.
OBJECTIVE: This study aimed to build the age-specific cranio-cortical correspondences for school-aged children and adolescents and investigate its differences to adults.
METHODS: Age-specific transcranial brain atlases (TBAs) were built with age groups: 6-8, 8-10, 10-12, 12-14, 14-16, and 16-18 years. We compared the performance in both transcranial locating and targeting when using the age-appropriate TBA versus the adult TBA (derived from adult population) for children.
RESULTS: These atlases provide age-specific probabilistic cranio-cortical correspondence at a high resolution (average scalp spacing of 2.8 mm). Significant differences in cranio-cortical correspondence between children/adolescents and adults were found: the younger the child, the greater the differences. For children (aged 6-12 years), locating and targeting errors when using the adult TBA reached 10 mm or more in the bilateral temporal lobe and frontal lobe. In contrast, the age-matched TBA reduced these errors to 4-5 mm, an approximately 50% reduction in error.
CONCLUSION: Our work provides an accurate and effective anatomical reference for studies in children and adolescents.