Arteriosclerosis, thrombosis, and vascular biology · 2007
In vivo evidence for a role of adipose tissue SR-BI in the nutritional and hormonal regulation of adiposity and cholesterol homeostasis.
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Yvan-Charvet Laurent, Bobard Alexandre, Bossard Pascale, Massiéra Florence, Rousset Xavier, Ailhaud Gérard, Teboul Michèle, Ferré Pascal, Dagher Georges, Quignard-Boulangé Annie
Аннотация
OBJECTIVES: This study examines the role of insulin and angiotensin II in high-density lipoprotein (HDL) metabolism by focusing on the regulation and function of scavenger receptor type-BI (SR-BI) in adipose tissue.
METHODS AND RESULTS: Insulin or angiotensin II injection in wild-type mice induced a decrease in circulating HDL and it was associated with the translocation of SR-BI from intracellular sites to the plasma membrane of adipose tissue. Refeeding upregulated adipose HDL selective cholesteryl esters uptake and SR-BI proteins through transcriptional and posttranscriptional mechanisms. This occurred along with a decrease in serum HDL and an increase in adipose cholesterol content. Similar results were obtained with transgenic mice overexpressing locally angiotensinogen in adipose tissue. In adipose 3T3-L1 cell line, HDL induced lipogenesis by increasing liver X receptor binding activity. This mechanism was dependent of insulin and angiotensin II.
CONCLUSIONS: Our results raise the possibility that adipose tissue SR-BI translocation might be a link between adipose tissue lipid storage and HDL clearance.
METHODS AND RESULTS: Insulin or angiotensin II injection in wild-type mice induced a decrease in circulating HDL and it was associated with the translocation of SR-BI from intracellular sites to the plasma membrane of adipose tissue. Refeeding upregulated adipose HDL selective cholesteryl esters uptake and SR-BI proteins through transcriptional and posttranscriptional mechanisms. This occurred along with a decrease in serum HDL and an increase in adipose cholesterol content. Similar results were obtained with transgenic mice overexpressing locally angiotensinogen in adipose tissue. In adipose 3T3-L1 cell line, HDL induced lipogenesis by increasing liver X receptor binding activity. This mechanism was dependent of insulin and angiotensin II.
CONCLUSIONS: Our results raise the possibility that adipose tissue SR-BI translocation might be a link between adipose tissue lipid storage and HDL clearance.
Предметные рубрики MeSH
3T3-L1 CellsATP Binding Cassette Transporter 1ATP-Binding Cassette TransportersAdipocytesAdipose TissueAdiposityAngiotensin IIAngiotensinogenAnimalsCell MembraneCholesterolCholesterol, HDLDNA-Binding ProteinsEatingEpididymisHomeostasisInsulinLipogenesisLiver X ReceptorsMaleMiceMice, TransgenicOrphan Nuclear ReceptorsProtein TransportRNA, MessengerReceptors, Cytoplasmic and NuclearScavenger Receptors, Class BSterol Regulatory Element Binding Protein 1Time FactorsTranscription, GeneticTriglycerides