Drug and chemical toxicology · 2024
Acute toxicity and biodistribution assessment of quantum dots conjugated to lectins from Schinus terebinthifolia leaves (SteLL) and Punica granatum sarcotesta (PgTeL).
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Oliveira Raquel Cordeiro de, Silva Abdênego Rodrigues da, Alves Robson Raion de Vasconcelos, de Barros Matheus Cavalcanti, Souza Talita Giselly Dos Santos, Oliveira Alisson Macário de, Patriota Leydianne Leite de Siqueira, Guedes Paiva Patrícia Maria, Tenório Fernanda das Chagas Ângelo Mendes, Filho Paulo Euzébio Cabral, Fontes Adriana, Napoleão Thiago Henrique, Oliveira Mércia Liane de, França Elvis Joacir de
Аннотация
This work reports the in vivo investigation of telluride cadmium quantum dots (CdTe QDs) conjugated to plant lectins from Schinus terebinthifolia (SteLL) and Punica granatum (PgTeL) for acute toxicity and genotoxicity in healthy mice and 24-h biodistribution in sarcoma 180-bearing animals. Acute toxicity data indicated their safety, despite some histopathological alterations. Comet assay revealed that the QDs-PgTeL group presented a higher damage index and frequency of damage than the negative control. The micronucleus test did not reveal a genotoxic effect. The 24-h biodistribution study showed a major uptake of cadmium by the liver, spleen, and kidneys. A greater accumulation of cadmium was found in tumors of the QDs-SteLL group. In conclusion, the biodistribution study showed no influence of the studied lectins in the absorption of QDs by different organs and that the conjugation of SteLL resulted in increased targeting of QDs to sarcoma 180 cells, suggesting a potential theranostic application in cancer.