eLife · 2024
Tissue-specific O-GlcNAcylation profiling identifies substrates in translational machinery in Drosophila mushroom body contributing to olfactory learning.
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Yu Haibin, Liu Dandan, Zhang Yaowen, Tang Ruijun, Fan Xunan, Mao Song, Lv Lu, Chen Fang, Qin Hongtao, Zhang Zhuohua, van Aalten Daan M F, Yang Bing, Yuan Kai
Аннотация
OBJECTIVE: Isolated sphenoid sinus disease (ISSD) is a relatively uncommon disease. In this study, we investigate the diagnosis and pathology of ISSD and compare endoscopic treatment with powered instrumentation with conventional surgical instruments for ISSD.
METHODS: Ninety-six out of 2,263 patients who underwent endoscopic surgery were diagnosed with ISSD by nasal endoscopy and computed tomography scan. Ninety-six cases of confirmed ISSD were treated by endoscopic sphenoidotomy, of which 44 cases were operated using powered instrumentation and 52 using conventional instruments. All patients were followed up for a period ranging from 18 to 54 months (mean 26 months) and the surgical outcomes were retrospectively reviewed.
RESULTS: The pathological findings of these patients included sphenoid sinusitis, fungal disease, sphenoid cyst, inverted papilloma, malignant tumor, sphenoid polyp, and foreign body. The most common initial symptom was headache, followed by visual changes and nasal symptoms. After endoscopic surgery, drainage of the sphenoid was accomplished in 87 of the 96 patients (91%). Of all patients, 9.4% (9/96) had recurrent incidence, 22% (21/96) sphenoid ostium synechia, and 51% (49/96) partial middle turbinectomy. Comparing the surgical outcomes between two operative approaches, recurrent incidence, sphenoid ostium synechia, and partial middle turbinectomy were significantly lower in the powered instrumentation group (2, 7, and 14%) than in the conventional instrument group (15, 35, and 83%;p < 0.05). No serious complication occurred in either group.
CONCLUSIONS: Powered instrumentation is more effective than conventional instruments in the treatment of ISSD and provides a minimally invasive surgical approach to the sphenoid sinus.
METHODS: Ninety-six out of 2,263 patients who underwent endoscopic surgery were diagnosed with ISSD by nasal endoscopy and computed tomography scan. Ninety-six cases of confirmed ISSD were treated by endoscopic sphenoidotomy, of which 44 cases were operated using powered instrumentation and 52 using conventional instruments. All patients were followed up for a period ranging from 18 to 54 months (mean 26 months) and the surgical outcomes were retrospectively reviewed.
RESULTS: The pathological findings of these patients included sphenoid sinusitis, fungal disease, sphenoid cyst, inverted papilloma, malignant tumor, sphenoid polyp, and foreign body. The most common initial symptom was headache, followed by visual changes and nasal symptoms. After endoscopic surgery, drainage of the sphenoid was accomplished in 87 of the 96 patients (91%). Of all patients, 9.4% (9/96) had recurrent incidence, 22% (21/96) sphenoid ostium synechia, and 51% (49/96) partial middle turbinectomy. Comparing the surgical outcomes between two operative approaches, recurrent incidence, sphenoid ostium synechia, and partial middle turbinectomy were significantly lower in the powered instrumentation group (2, 7, and 14%) than in the conventional instrument group (15, 35, and 83%;p < 0.05). No serious complication occurred in either group.
CONCLUSIONS: Powered instrumentation is more effective than conventional instruments in the treatment of ISSD and provides a minimally invasive surgical approach to the sphenoid sinus.