Stereotactic radiosurgery (SRS) for patients with brainstem cerebral cavernous malformations (CCMs): an international, multicentric study.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
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Dayawansa Sam, Dumot Chloe, Mantziaris Georgios, Xu Zhiyuan, Pikis Stylianos, Peker Selcuk, Samanci Yavuz, Ardor Gokce D, Nabeel Ahmed M, Reda Wael A, Tawadros Sameh R, Abdelkarim Khaled, El-Shehaby Amr M N, Eldin Reem M Emad, Elazzazi Ahmed H, Moreno Nuria Martínez, Álvarez Roberto Martínez, Liscak Roman, May Jaromir, Mathieu David, Tourigny Jean-Nicolas, Tripathi Manjul, Rajput Akshay, Kumar Narendra, Kaur Rupinder, Picozzi Piero, Franzini Andrea, Speckter Herwin, Hernandez Wenceslao, Brito Anderson, Warnick Ronald E, Alzate Juan, Kondziolka Douglas, Bowden Greg N, Patel Samir, Sheehan Jason P
Аннотация
Brainstem cerebral cavernous malformations (CCM) are clinically more aggressive compared to superficial CCMs. Due to their location, resection can be challenging, making stereotactic radiosurgery (SRS) an attractive alternative for symptomatic patient. Brainstem CCM patients (n = 170) were treated with Gamma Knife SRS at 11 radiosurgical centers. Hemorrhagic risk reduction, risk factors of post-SRS hemorrhage, and clinical outcomes were retrospectively analyzed. Most patients had a single (165/170 patients) brainstem CCMs treated; the majority of CCMs (165/181) presented with bleeding. Single-session SRS decreased the risk of repeat hemorrhage in patients with hemorrhagic brainstem CCM (HR: 0.17, p < 0.001) using recurrent multivariate analysis. The annual hemorrhage rate decreased from 14.8 per 100 CCM-years before SRS to 2.3 after treatment. Using univariate Cox-analysis, the probability of a new hemorrhages after SRS was reduced for patient older than 35 years (HR = 0.21, p = 0.002) and increased with a margin dose > 13 Gy (HR = 2.57, p = 0.044). Adverse radiation effect (ARE) occurred in 9 patients (5.3%) and was symptomatic in four (2.4%). At a median follow-up of 3.4 years (Inter-quartile range: 5.4), 13 patients (8.0%) had a worsened clinical status, with the treated CCM being the cause in 5.6% (10) of the patients. Single-session SRS decreased the risk of repeat hemorrhage in patients with hemorrhagic brainstem CCM and conveyed this benefit with a low risk of advrse radiation effects (ARE) and worsening clinical status.