Schizophrenia bulletin · 2026
Clinical Significance of Psychotic Experiences in Preadolescent Children with Non-Psychotic Mental Disorders-The Danish High Risk and Resilience Study, VIA 11.
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Gregersen Maja, Rohd Sinnika Birkehøj, Søndergaard Anne, Brandt Julie Marie, Jepsen Jens Richardt Møllegaard, Veddum Lotte, Knudsen Christina Bruun, Andreassen Anna Krogh, Hjorthøj Carsten, Krantz Mette Falkenberg, Greve Aja Neergaard, Mors Ole, Nordentoft Merete, Hemager Nicoline, Thorup Anne Amalie Elgaard
Аннотация
BACKGROUND AND HYPOTHESIS: Psychotic experiences (PE) are associated with higher severity of other psychopathology in adults and adolescents with non-psychotic mental disorders. Knowledge on the clinical significance of PE in children with non-psychotic mental disorders, which may help improve early identification of need for treatment, is sparse.
STUDY DESIGN: In this cross-sectional study, preadolescent children (n = 157, mean age 12.0, SD 0.2, range 11.1-12.7 years) at familial high-risk of schizophrenia (n = 78) or bipolar disorder (n = 40) and population-based controls (n = 39) with non-psychotic Axis I mental disorders during middle childhood were assessed for PE, dimensional psychopathology, multimorbidity, global functioning, and impact of psychopathology.
STUDY RESULTS: Children with PE had higher scores on total (Cohen's d 0.40, P = .02) and internalizing dimensional symptoms (Cohen's d 0.42, P = .02) and higher rates of multimorbidity, ie, meeting criteria for more than one mental disorder (OR 2.2, P = .04), than those without PE after accounting for familial risk. Children with PE had higher rates of self-reported impact of psychopathology after accounting for number of concurrent mental disorders and familial risk (OR 2.5, P = .01). The levels of externalizing symptoms and global functioning were not significantly different in those with and without PE.
CONCLUSIONS: Presence of PE marks increased severity of concurrent non-psychotic psychopathology including more self-perceived impact of psychopathology in preadolescent children with mental disorders. PE could indicate a higher need for treatment and should be routinely assessed in child and adolescent mental health services.
STUDY DESIGN: In this cross-sectional study, preadolescent children (n = 157, mean age 12.0, SD 0.2, range 11.1-12.7 years) at familial high-risk of schizophrenia (n = 78) or bipolar disorder (n = 40) and population-based controls (n = 39) with non-psychotic Axis I mental disorders during middle childhood were assessed for PE, dimensional psychopathology, multimorbidity, global functioning, and impact of psychopathology.
STUDY RESULTS: Children with PE had higher scores on total (Cohen's d 0.40, P = .02) and internalizing dimensional symptoms (Cohen's d 0.42, P = .02) and higher rates of multimorbidity, ie, meeting criteria for more than one mental disorder (OR 2.2, P = .04), than those without PE after accounting for familial risk. Children with PE had higher rates of self-reported impact of psychopathology after accounting for number of concurrent mental disorders and familial risk (OR 2.5, P = .01). The levels of externalizing symptoms and global functioning were not significantly different in those with and without PE.
CONCLUSIONS: Presence of PE marks increased severity of concurrent non-psychotic psychopathology including more self-perceived impact of psychopathology in preadolescent children with mental disorders. PE could indicate a higher need for treatment and should be routinely assessed in child and adolescent mental health services.