Pancreas · 2026
Determination of Psychological Comorbidities in Children With Acute Recurrent or Chronic Pancreatitis Referred for Total Pancreatectomy With Islet Autotransplantation Evaluation: A Single-Center Study.
СтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод в очереди
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Kramer Hailey, Santucci Neha R, Lee Olivia, Gurria Juan P, Jenkins Todd, Rich Kristin, Hartzell Cheryl, Abu-El-Haija Maisam
Аннотация
BACKGROUND: Multiple psychological factors and related comorbidities affect children with chronic pancreatitis (CP) or acute recurrent pancreatitis (ARP). We aimed to describe the frequency of psychological symptoms/diagnoses in children with CP/ARP and predict the severity of the disease burden based on these factors.
METHODS: We retrospectively identified patients aged 5 years or younger with a prior history of CP/ARP who were evaluated by a pediatric psychologist as part of their evaluation for total pancreatectomy with islet autotransplantation (TPIAT) at a single center. Symptoms of psychological disorders and prior psychological diagnoses were identified. Patients and their families completed pain questionnaires as part of clinical care. Demographic and pancreatic disease data were collected from electronic medical records.
KEY RESULTS: Of 105 children (mean age 12.1 ± 3.5 y, 54.3% females, 84.4% white), 37.1% had a psychological diagnosis [20.0% anxiety, 13.3% depression, 23.8% attention-deficit hyperactivity disorder (ADHD), 4.8% post-traumatic stress disorder (PTSD)] while 86.7% displayed symptoms based on DSM-5 criteria (75.7% anxiety, 32.3% depression, 21.1% suicidal ideation, and 40.2% panic). Regarding pain, 38.8% of patients reported daily abdominal pain, 24.3% weekly, 14.6% monthly, and 22.3% less than once per month. In the 6 months prepsychology appointment, 70.9% used opioids in the inpatient setting, 25.7% used opioids in the outpatient setting, and 45.2% were on a neuromodulator to control their pain. The median pain severity did not statistically differ by psychological diagnosis or symptoms ( P =0.16).
CONCLUSION: There was a high prevalence of psychological diagnoses/symptoms in patients with ARP/CP, including suicidal ideation. This highlights the need for future prospective studies to explore the role of mental health in disease outcomes in children with CP or ARP.
METHODS: We retrospectively identified patients aged 5 years or younger with a prior history of CP/ARP who were evaluated by a pediatric psychologist as part of their evaluation for total pancreatectomy with islet autotransplantation (TPIAT) at a single center. Symptoms of psychological disorders and prior psychological diagnoses were identified. Patients and their families completed pain questionnaires as part of clinical care. Demographic and pancreatic disease data were collected from electronic medical records.
KEY RESULTS: Of 105 children (mean age 12.1 ± 3.5 y, 54.3% females, 84.4% white), 37.1% had a psychological diagnosis [20.0% anxiety, 13.3% depression, 23.8% attention-deficit hyperactivity disorder (ADHD), 4.8% post-traumatic stress disorder (PTSD)] while 86.7% displayed symptoms based on DSM-5 criteria (75.7% anxiety, 32.3% depression, 21.1% suicidal ideation, and 40.2% panic). Regarding pain, 38.8% of patients reported daily abdominal pain, 24.3% weekly, 14.6% monthly, and 22.3% less than once per month. In the 6 months prepsychology appointment, 70.9% used opioids in the inpatient setting, 25.7% used opioids in the outpatient setting, and 45.2% were on a neuromodulator to control their pain. The median pain severity did not statistically differ by psychological diagnosis or symptoms ( P =0.16).
CONCLUSION: There was a high prevalence of psychological diagnoses/symptoms in patients with ARP/CP, including suicidal ideation. This highlights the need for future prospective studies to explore the role of mental health in disease outcomes in children with CP or ARP.
Предметные рубрики MeSH
HumansFemaleChildPancreatectomyIslets of Langerhans TransplantationMaleRetrospective StudiesAdolescentPancreatitis, ChronicComorbidityRecurrenceTransplantation, AutologousPancreatitisAcute DiseaseChild, PreschoolDepressionAnxietySeverity of Illness IndexStress Disorders, Post-TraumaticSurveys and Questionnaires