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DOI 10.1038/s43587-025-01035-5

Медицинская библиотека · Nature aging · 2026

The Population Neuroscience-Dementia Syndemics Framework to better understand global sex and gender-based risk in low- and middle-income countries.

Shaaban C Elizabeth, Suryadevara Vidyani, Hill Ashley V, Milani Sadaf Arefi, Agarwal Puja, Aggarwal Neelum T, Akinyemi Rufus O, Alladi Suvarna, Brown Monique J, Caldwell Jessica Z K, Caramelli Paulo, DuBose Lyndsey, Ellajosyula Ratnavalli, Esiaka Darlingtina K, Gibson Allison, Griffith Patrick, Harper Joshua, Karanja Wambūi, Li Wei, Llibre-Guerra Jorge J, Loi Samantha M, Mielke Michelle M, Molina-Henry Doris P, Ogunniyi Adesola, Pudumjee Shehroo, Stites Shana D, Sundermann Erin, Turner Arlener D, Vila-Castelar Clara, Viswanathan Jayalakshmi, Trani Jean-François, Babulal Ganesh M, Diversity and Disparities Professional Interest Area’s Low- and Middle-Income Countries Work Group of the International Society to Advance Alzheimer’s Research and Treatment (ISTAART), Diversity and Disparities Professional Interest Area’s Sex and Gender Special Interest Group of the International Society to Advance Alzheimer’s Research and Treatment (ISTAART)

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Аннотация

Globally, the burden of dementia profoundly affects low- and middle-income countries (LMICs), with a greater burden and risk for late-life women than men. Structural and social determinants of health, crucial constructs conferring risk and protection from later-life dementia, are relatively understudied, yet essential in LMICs. Typical neuroscience studies have historically been small, with highly selected samples that do not generalize well to target populations in LMICs. To better understand gender and sex differences in dementia risk in LMICs, this Perspective lays out a guiding framework for a global dementia research plan-the Population Neuroscience-Dementia Syndemics Framework. Population neuroscience considers the brain in a multilevel context, from a lifecourse perspective, using tools to enhance internal and external validity, while syndemics suggest that diseases and social conditions may cluster and interact in populations with syndemic risk factors-sociocultural, political, economic, and environmental factors that promote stress pathways and disease.

Для цитирования: Shaaban C Elizabeth, Suryadevara Vidyani, Hill Ashley V, Milani Sadaf Arefi, Agarwal Puja, Aggarwal Neelum T, Akinyemi Rufus O, Alladi Suvarna, Brown Monique J, Caldwell Jessica Z K, Caramelli Paulo, DuBose Lyndsey, Ellajosyula Ratnavalli, Esiaka Darlingtina K, Gibson Allison, Griffith Patrick, Harper Joshua, Karanja Wambūi, Li Wei, Llibre-Guerra Jorge J, Loi Samantha M, Mielke Michelle M, Molina-Henry Doris P, Ogunniyi Adesola, Pudumjee Shehroo, Stites Shana D, Sundermann Erin, Turner Arlener D, Vila-Castelar Clara, Viswanathan Jayalakshmi, Trani Jean-François, Babulal Ganesh M, Diversity and Disparities Professional Interest Area’s Low- and Middle-Income Countries Work Group of the International Society to Advance Alzheimer’s Research and Treatment (ISTAART), Diversity and Disparities Professional Interest Area’s Sex and Gender Special Interest Group of the International Society to Advance Alzheimer’s Research and Treatment (ISTAART). The Population Neuroscience-Dementia Syndemics Framework to better understand global sex and gender-based risk in low- and middle-income countries.. Nature aging. 2026. DOI: 10.1038/s43587-025-01035-5.

Предметные рубрики MeSH

HumansDementiaDeveloping CountriesNeurosciencesRisk FactorsFemaleMaleSex FactorsGlobal Health
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