Результаты поиска

Seroprevalence of Toxoplasma gondii and Borrelia burgdorferi infections in patients with multiple sclerosis in Poland.

Multiple sclerosis (MS) is a chronic, demyelinating disease of the central nervous system that affects mainly young people. It is believed that the autoimmune process observed in the pathogenesis of MS is influenced by a complex interaction between genetic and environmental factors, including infectious agents. The results of this study suggest the protective role of Toxoplasma gondii infections in MS. Interestingly, high Toxoplasma IgM seropositivity in MS patients receiving immunomodulatory drugs (IMDs) was identified. On the other hand, Borrelia infections seem to be positively associated w…

Factors Contributing to the Development of Neuropsychiatric Manifestations in Persons With Multiple Sclerosis: A Systematic Review.

Multiple sclerosis (MS) is the most common chronic demyelinating disease affecting the central nervous system (CNS) and is distinguished by neuroinflammation and neurodegeneration. It has four categories based on clinical course, with relapsing-remitting being the most common type. MS predominantly manifests with motor and sensory dysfunctions. However, neuropsychiatric manifestations such as depression, anxiety, schizophrenia, and bipolar disorder are not uncommon. Various factors may contribute to the development of these manifestations; therefore, this study aimed to unravel them. This syst…

Efficacy and clinical outcomes of percutaneous treatments for trigeminal neuralgia secondary to multiple sclerosis.

BACKGROUND: People with Multiple Sclerosis (MS) have a 20-fold higher risk of developing trigeminal neuralgia compared to the general population. Treating trigeminal neuralgia in these patients is particularly challenging due to reduced tolerance and increased side effects from medications. When no neurovascular conflict exist, percutaneous treatments are usually the first option after drug therapy. According to the literature, treatment outcomes for MS-associated trigeminal neuralgia show higher relapse rates and lower rates of sustained pain relief compared to primary trigeminal neuralgia, o…

Сравнительный анализ инструментов скрининга на депрессию при множественном склерозе: последствия для диагностики и распространенности.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: БДИ-II по-прежнему широко используется для оценки важности депрессивных симптомов у лиц с MS (PwMS), несмотря на недавние рекомендации об использовании сокращенной и адаптированной формы этого скринингового инструмента (BDI-FS). МЕТОД: Мы сравнили распространенность депрессивных симптомов в 329 PwMS, которые закончили как BDI-II, так и BDI-FS, и проверили соглашение между обоими инструментами скрининга. Результаты: БДИ-FS свидетельствует о более низкой общей распространенности депрессии, но не в серьезных случаях. Заключение: Крайне важно повысить осведомленность о потен

Migraine in the multiple sclerosis prodrome: a prospective nationwide cohort study in pregnant women.

BACKGROUND: People with multiple sclerosis (MS) have an increased risk of migraine. However, little is known about migraine and other headaches during the prodromal phase (before MS symptom onset). Our objective was to study the risk of migraine in women with MS before MS onset. METHODS: A nationwide, prospective cohort study of women participating in the Norwegian Mother, Father, and Child cohort study 1999-2008. The women reported the occurrence of migraine and other headaches prior to or during pregnancy. We identified women who later developed MS through data linkage with national health …

Связь между изображением тела и психологическими результатами в множестве склерозов. Систематический обзор.

Множественный склероз (MS) — аутоиммунное состояние, в котором изображение тела может быть изменено из-за целого ряда биопсихосоциальных факторов. Цель этого обзора заключалась в изучении вопроса о том, существует ли связь между изображением тела и психологическими результатами в НР, с тем чтобы направлять развитие клинического вмешательства. МЕТОДЫ: В ноябре 2023 года был систематически проведен поиск баз данных PsycINFO, Medline, CINAHL и Scopus на предмет проведения соответствующих исследований с использованием терминов, касающихся MS и изображения тела. В него были включены количественные

Совпадение в аннотации оригинала
BACKGROUND: Multiple sclerosis (MS) is a demyelinating autoimmune condition, in which body image may be altered due to a range of biopsychosocial factors. The aim of this review was to examine whether there is a relationship between body image and psychological outcomes in MS, in order to guide clinical intervention development. METHODS: PsycINFO, Medline, …

Воспаляющие белки, связанные с депрессией при множественном склерозе: систематический обзор и метаанализ.

ИСТОРИЯ ВОПРОСА: 50% У людей с множественным склерозом (MS) депрессия. Депрессия сопровождается увеличением количества подстрекательских белков. Этот метаанализ резюмировал данные о воспламенительных концентрациях белка и уровне депрессии у людей с MS. МЕТОДЫ: Мы провели метаанализ исследований, измеряющих воспламенительные концентрации белков и уровень депрессии у людей с MS с помощью поиска базы данных английской литературы (до октября) 2024) и ручного поиска ссылок. Была также проведена оценка качества доказательств.Результаты: Fifteen исследования, связанные с измерением воспалительных бел

Совпадение в аннотации оригинала
BACKGROUND: Up to 50% of individuals with multiple sclerosis (MS) experience depression. Depression has been accompanied by increases in inflammatory proteins. This meta-analysis summarized the data on inflammatory protein concentrations and level of depression in individuals with MS. METHODS: We performed a meta-analysis of studies measuring inflammatory p…

Благодарность в качестве посредника между статусом занятости и чувством удовлетворенности у людей с множественным склерозом.

Несмотря на то, что в ходе предыдущих исследований были исследованы прогнозы занятости лиц с множественным склерозом (МС), ни в одном из исследований не рассматривалась связь между статусом занятости и чувством достижения результатов среди лиц, имеющих НР, и то, как благодарность может повлиять на эти отношения. ЦЕЛЬ: Цель данного исследования заключалась в изучении вопроса о том, позволяет ли благодарность уменьшить взаимосвязь между статусом занятости и чувством достижения результатов. МЕТОДЫ: В этом перекрестном исследовании приняли участие 291 участник с MS (Mage = 45,77 лет; SD = 10,09 го

Совпадение в аннотации оригинала
BACKGROUND: Although prior research has investigated the predictors of employment of people with multiple sclerosis (MS), no studies have examined the relationship between employment status and sense of accomplishment among individuals with MS and how gratitude can affect that relationship. OBJECTIVE: The purpose of this study was to examine whether gratitu…

Воздействие физических упражнений, MitoQ и их комбинация на воспаление и гениальное выражение в женщинах с множественным склерозом.

Множественный склероз (MS) — хроническое аутоиммунное заболевание, затрагивающее центральную нервную систему. Нынешние методы лечения направлены на регулирование симптомов и медленных темпов развития заболеваний, однако существует необходимость в эффективных мерах, направленных на устранение основных причин заболеваний. В этом исследовании мы изучили последствия физических упражнений, MitoQ (целевой антиоксидант митохондрии) и их комбинацию с генным выражением различных биомаркеров, связанных с MS, у постменопаузальных и предменопаузальных женщин. Мы измерили интерлейкин-6 (IL-6) и ключевые мо

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system. Current treatments aim to manage symptoms and slow disease progression, but there is a need for effective interventions that target underlying disease mechanisms. In this study, we investigated the effects of exercise, MitoQ (a mitochondria-targeted antioxidant), an…

Удовлетворенность пациентами с множественным склерозом Терифлуномида: систематический обзор наблюдений.

ИССЛЕДОВАНИЯ: Исследование степени удовлетворенности лечением множественных склерозов (MS) имеет важнейшее значение для обеспечения ориентированного на пациентов ухода и улучшения соблюдения требований к лечению. Мы поставили перед собой цель провести обзор исследований, в ходе которых был использован вопросник по лечению сатисфакции для лекарств (TSCM) для оценки степени удовлетворенности пациентов с синдромом терафлюном. МЕТОДЫ: PubMed, Scopus, Web of Science, PsycINFO, Библиотека Кокрана и Стипендиат Google 2 - независимые эксперты по рассмотрению для выявления всех соответствующих исследов

Совпадение в аннотации оригинала
BACKGROUND: Research on treatment satisfaction with treatments of multiple sclerosis (MS) is essential for delivering patient-centered care and improving treatment adherence. We aimed to review studies that have used the Treatment Satisfaction Questionnaire for Medication (TSQM) to assess treatment satisfaction with teriflunomide in patients with MS. METHOD…

Automatic segmentation of the choroid plexuses: Method and validation in controls and patients with multiple sclerosis.

Choroid Plexuses (ChP) are structures located in the ventricles that produce the cerebrospinal fluid (CSF) in the central nervous system. They are also a key component of the blood-CSF barrier. Recent studies have described clinically relevant ChP volumetric changes in several neurological diseases including Alzheimer's, Parkinson's disease, and multiple sclerosis (MS). Therefore, a reliable and automated tool for ChP segmentation on images derived from magnetic resonance imaging (MRI) is a crucial need for large studies attempting to elucidate their role in neurological disorders. Here, we pr…

Analysis of Cdx2 VDR gene polymorphism rs11568820 in association with multiple sclerosis in Slovaks.

Vitamin D deficiency is involved in the pathogenesis of multiple sclerosis (MS), a severe autoimmune demyelinating disease of the central nervous system. The gene polymorphism Cdx-2 (rs11568820, G/A) seriously influences the trancriptional activity of the vitamin D receptor (VDR) that binds the vitamin D responsive elements of target genes including HLA-DRB1*15. The aim of the present study in Slovaks was to analyse the association of Cdx-2 variants with the risk of MS and disability progression, and to assess the DRB1*15:01 allele as a possible confounding factor. In total, 493 MS patients an…

Vitamin D deficiency in relation with the systemic and central inflammation during multiple sclerosis.

BACKGROUND: During the last decade, vitamin D (VitD) has become a topic of interest in immune regulation, especially in multiple sclerosis (MS) disease. Amongst the wide range of effects reported for this vitamin on the immune system, a regulatory role on cytokines production has been described. Our aim is to analyze the status of VitD and its correlation with the circulating inflammation and the intrathecal humoral response during MS. METHODS: We analyzed samples of 318 individuals: 108 MS patients and 210 controls. Determination of 25-(OH) VitD3 level in serum was made using electrochemilum…

Interaction of the Gut Microbiome and Immunity in Multiple Sclerosis: Impact of Diet and Immune Therapy.

The bidirectional communication between the gut and central nervous system (CNS) through microbiota is known as the microbiota-gut-brain axi … ut immunity is critically involved in gut-brain communication during health and diseases, including multiple sclerosis (MS). The gut microbiota can influence the development and function of gut immunity, and conversely, the innate and adaptive mucosal immunity can influence microbiota composition. Gut and systemic immunity, along with gut microbiota, are perturbed i …

Benefits of a mosaic approach for assessing cortical atrophy in individual multiple sclerosis patients.

OBJECTIVE: Cortical gray matter (GM) atrophy plays a central role in multiple sclerosis (MS) pathology. However, it is not commonly assessed in clinical routine partly because a number of methodological problems hamper the development of a robust biomarker to quantify GM atrophy. In previous work, we have demonstrated the clinical utility of the "mosaic approach" (MAP) to assess individual GM atrophy in the motor neuron disease spectrum and frontotemporal dementia. In this study, we investigated the clinical utility of MAP in MS, comparing this novel biomarker to existing methods for computing…

Cannabis and Cannabinoids in Multiple Sclerosis: From Experimental Models to Clinical Practice-A Review.

BACKGROUND: As far as 80% of people diagnosed with multiple sclerosis (MS) experience disabling symptoms in the course of the disease, such as spasticity and neuropathic pain. As first-line symptomatic therapy is associated with important adverse reactions, cannabinoids have become increasingly popular among patients with MS. This review intends to provide an overview of the evidence of the role of cannabinoids in treating symptoms related to MS and to encourage further research on this matter. AREAS OF UNCERTAINTY: To date, the evidence supporting the role of cannabis and its derivatives in …

The validation of the Italian version of multiple sclerosis neuropsychological screening questionnaire in Huntington's disease.

INTRODUCTION: Multiple sclerosis neuropsychological questionnaire (MSNQ) is a brief questionnaire useful for screening patient's and informant's self-perception of cognitive dysfunctions in daily life activities. Our study aims to evaluate the MSNQ validity in Huntington's disease (HD) mutation carriers and to correlate MSNQ scores with neurological, cognitive, and behavioral variables. METHODS: The study was conducted on a sample of 107 subjects from presymptomatic to the middle stage of HD recruited at LIRH Foundation and C.S.S. Mendel Institute in Rome. Unified Huntington's Disease Rating …

Pain and participation in social activities in people with relapsing remitting and progressive multiple sclerosis.

BACKGROUND: Differences in pain between subtypes of multiple sclerosis are understudied. OBJECTIVE: To compare the prevalence of pain, and the association between pain and: (a) pain interference and (b) social participation in people with relapsing-remitting multiple sclerosis and progressive multiple sclerosis. METHODS: Participants completed the McGill Pain Questionnaire Short-Form-2, Pain Effects Scale and Ability to Participate in Social Roles and Activities-V2.0 questionnaires. We tested the association between multiple sclerosis subtype, pain severity, and pain interference/social part…

Cost-consequence analysis of ofatumumab for the treatment of relapsing-remitting multiple sclerosis in Canada.

Aim: The costs and consequences of initial and delayed ofatumumab treatment were evaluated in relapsing-remitting multiple sclerosis with active disease in Canada. Materials & methods: A Markov cohort model was used (10-year horizon, annual cycle length, 1.5% discounting). Scenario analyses examined ofatumumab as first-line treatment versus 3 and 5 years following switch from commonly used first-line therapies. Results: Ofatumumab resulted in improvements in clinical outcomes (relapses and disease progression) and productivity (employment and full-time work), and reduction of economic burden (…

Medication adherence and health outcomes in persons with multiple sclerosis treated with dimethyl fumarate.

BACKGROUND: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system that particularly affects people in their 30s. Oral disease-modifying therapy (DMT) offers a simple dosage form, good efficacy and safety. Dimethyl fumarate (DMF) is a frequently prescribed oral DMT medication worldwide. The aim of this study was to evaluate the impact of medication adherence on health outcomes in Slovenian persons with MS treated with DMF. METHODS: Our retrospective cohort study included persons with relapsing-remitting MS on DMF treatment. The medication adherence was evaluat…