Wei sheng yan jiu = Journal of hygiene research · 2025
[Association between serum vitamin D levels and common comorbidities of frailty among community-dwelling older people under varying inflammatory conditions].
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Li Cheng, Li Yuqian, Zhang Ting, Wu Hua, Jia Huijuan, Wu Hua, Song Pengkun, Zhang Jian
Аннотация
OBJECTIVE: To investigate the association between serum vitamin D levels and common frailty-related comorbidities, including sarcopenia and dysphagia, in community-dwelling older people, and to analyze the influence of varying inflammatory conditions.
METHODS: From August to December 2020, 894 community-dwelling older people aged ≥65 years were recruited from Guangdong, Jiangsu, and Inner Mongolia. Data were collected through questionnaire surveys, physical measurements, sarcopenia assessment(grip strength, gait speed, body composition), dysphagia evaluation, and blood biomarker testing(vitamin D, high-sensitivity C-reactive protein(hsCRP)). Multivariate Logistic regression models were employed to examine the associations between vitamin D and frailty-related comorbidities, as well as the interaction effects of inflammatory levels.
RESULTS: A total of 884 older people completed the survey. The prevalence of sarcopenia was 14.48%, and the prevalence of dysphagia(including suspected dysphagia) was 34.84%. The median levels of 25-(OH)D_2(0.28 ng/mL) and 25-(OH)D_3(24.69 ng/mL) in the dysphagia group were significantly lower than those in the non-dysphagia group(0.45 ng/mL and 27.18 ng/mL, respectively; P<0.01). A significant interaction was observed between 25-(OH)D_3 and hsCRP in relation to dysphagia(P<0.05). Subgroup analysis revealed that in older people with hsCRP<3 mg/L, 25-(OH)D_3 levels were negatively associated with suspected dysphagia(OR=0.98, 95%CI 0.96-0.99, P<0.05), whereas no significant association was found in those with hsCRP>3 mg/L.
CONCLUSION: Serum vitamin D levels in community-dwelling elderly individuals were significantly associated with swallowing function, and this association was influenced by inflammatory status: in the population with low inflammatory levels, serum vitamin D levels were negatively associated with the risk of dysphagia, while there was no significant association in the population with high inflammatory levels.
METHODS: From August to December 2020, 894 community-dwelling older people aged ≥65 years were recruited from Guangdong, Jiangsu, and Inner Mongolia. Data were collected through questionnaire surveys, physical measurements, sarcopenia assessment(grip strength, gait speed, body composition), dysphagia evaluation, and blood biomarker testing(vitamin D, high-sensitivity C-reactive protein(hsCRP)). Multivariate Logistic regression models were employed to examine the associations between vitamin D and frailty-related comorbidities, as well as the interaction effects of inflammatory levels.
RESULTS: A total of 884 older people completed the survey. The prevalence of sarcopenia was 14.48%, and the prevalence of dysphagia(including suspected dysphagia) was 34.84%. The median levels of 25-(OH)D_2(0.28 ng/mL) and 25-(OH)D_3(24.69 ng/mL) in the dysphagia group were significantly lower than those in the non-dysphagia group(0.45 ng/mL and 27.18 ng/mL, respectively; P<0.01). A significant interaction was observed between 25-(OH)D_3 and hsCRP in relation to dysphagia(P<0.05). Subgroup analysis revealed that in older people with hsCRP<3 mg/L, 25-(OH)D_3 levels were negatively associated with suspected dysphagia(OR=0.98, 95%CI 0.96-0.99, P<0.05), whereas no significant association was found in those with hsCRP>3 mg/L.
CONCLUSION: Serum vitamin D levels in community-dwelling elderly individuals were significantly associated with swallowing function, and this association was influenced by inflammatory status: in the population with low inflammatory levels, serum vitamin D levels were negatively associated with the risk of dysphagia, while there was no significant association in the population with high inflammatory levels.