Investigative ophthalmology & visual science · 2026
Mean Apparent Propagator MRI: A Potential Imaging Biomarker of Brain Microstructural Alterations in Basic-Type Intermittent Exotropia.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Shi Qinglei, Zhou Mengdi, Shi Diwei, Su Mengqi, Wang Zongshu, Cong Shiqing, Li Huixin, Zhang Haoran, Sun Yangfan, Zhao Ruijia, Hong Jie, Fu Jing, Guo Hua, Wang Renzhi, Wan Xiang, Liu Zhaohui
Аннотация
PURPOSE: This study aimed to investigate brain microstructural alterations in children with basic-type intermittent exotropia (IXT) using mean apparent propagator magnetic resonance imaging (MAP-MRI) and to analyze their correlations with clinical signs.
METHODS: MRI was performed on individuals with basic-type IXT and healthy controls using a 3T Siemens scanner with a 64-channel head coil. Three-dimensional T1-weighted and diffusion-weighted images were acquired. MAP-MRI parametric maps were reconstructed using the Laplace-constrained algorithm, with diffusion tensor imaging maps serving as a reference. Voxel-wise analysis and deterministic fiber tractography were conducted to investigate microstructural changes of cortical regions and visual pathway in basic-type IXT. Receiver operating characteristic analysis was performed to assess the discriminative performance of the MAP-MRI metrics. The correlations between MAP-MRI metrics in significant brain regions and clinical signs were also analyzed.
RESULTS: Seventy-eight individuals with basic-type IXT and 96 healthy controls were enrolled. MAP-MRI revealed extensive microstructural alterations in brain regions associated with binocular vision and oculomotor control, as well as cognition and emotion regulation (P < 0.01 at both the voxel and cluster levels). Receiver operating characteristic analysis demonstrated that MAP-MRI metrics exhibited excellent discriminative performance, with the highest area under the curve of 0.986. In addition, MAP-MRI metrics were correlated with disease severity and disease duration (P < 0.05).
CONCLUSIONS: MAP-MRI identified widespread microstructural alterations and their associations with clinical signs, providing valuable insights into the neural correlates underlying impaired binocular vision and oculomotor control in children with basic-type IXT. MAP-MRI metrics have the potential to serve as noninvasive imaging biomarkers for detecting IXT-related microstructural changes.
METHODS: MRI was performed on individuals with basic-type IXT and healthy controls using a 3T Siemens scanner with a 64-channel head coil. Three-dimensional T1-weighted and diffusion-weighted images were acquired. MAP-MRI parametric maps were reconstructed using the Laplace-constrained algorithm, with diffusion tensor imaging maps serving as a reference. Voxel-wise analysis and deterministic fiber tractography were conducted to investigate microstructural changes of cortical regions and visual pathway in basic-type IXT. Receiver operating characteristic analysis was performed to assess the discriminative performance of the MAP-MRI metrics. The correlations between MAP-MRI metrics in significant brain regions and clinical signs were also analyzed.
RESULTS: Seventy-eight individuals with basic-type IXT and 96 healthy controls were enrolled. MAP-MRI revealed extensive microstructural alterations in brain regions associated with binocular vision and oculomotor control, as well as cognition and emotion regulation (P < 0.01 at both the voxel and cluster levels). Receiver operating characteristic analysis demonstrated that MAP-MRI metrics exhibited excellent discriminative performance, with the highest area under the curve of 0.986. In addition, MAP-MRI metrics were correlated with disease severity and disease duration (P < 0.05).
CONCLUSIONS: MAP-MRI identified widespread microstructural alterations and their associations with clinical signs, providing valuable insights into the neural correlates underlying impaired binocular vision and oculomotor control in children with basic-type IXT. MAP-MRI metrics have the potential to serve as noninvasive imaging biomarkers for detecting IXT-related microstructural changes.