Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2018
Androgen receptor in salivary gland carcinoma: A review of an old marker as a possible new target.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Yeoh Chit Cheng, Dabab Nedal, Rigby Elyse, Chhikara Ritu, Akaev Iolia, Gomez Ricardo Santiago, Fonseca Felipe, Brennan Peter A, Rahimi Siavash
Аннотация
The role of the androgen receptor (AR) as an immunomarker for diagnosis of salivary gland duct carcinoma (SDC) is well known. Other non-squamous cell head and neck cancers (NSCC-HN), including a small subset of salivary gland cancers (SGCs), can also express AR. With the increase in effective and powerful new generation of anti-androgen agents and drugs administered orally, more targetable AR-driven NSCC-HN, such as subsets of SGCs, should be investigated for possible expression of AR. In this review, we focus on SGC subtypes, which could express AR and describe the main androgen deprivation therapy (ADT) strategies.
Предметные рубрики MeSH
AdenocarcinomaAdministration, OralAndrogen AntagonistsAndrostenesAnilidesAntineoplastic AgentsBenzamidesBiomarkers, TumorCarcinoma, Adenoid CysticCarcinoma, MucoepidermoidFemaleHumansMaleMolecular Targeted TherapyNitrilesPhenylthiohydantoinReceptors, AndrogenSalivary DuctsSalivary Gland NeoplasmsTosyl Compounds