Tau-PET correlates of mild behavioral impairment in preclinical and prodromal Alzheimer's disease: A head-to-head comparison of Flortaucipir and MK6240.
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Bizzi Isabella, Macedo Arthur C, Trudel Lydia, Therriault Joseph, Rahmouni Nesrine, Lussier Firoza Z, Tissot Cécile, Bezgin Gleb, Aumont Étienne, Chan Tevy, Hosseini Seyyed Ali, Oliva-Lopez Delphine, Gonçalves Marina Pereira, Povala Guilherme, Ferreira Pamela C L, Bellaver Bruna, Amaral Livia, Ruppert Emma, Medeiros Marina Scop, Mroué Rayan, Rocha Andréia, Ng Kok Pin, Zimmer Eduardo R, Masdeu Joseph, Pascual Belen, Lowe Val J, Oh Hwamee, Soleimani-Meigooni David N, Fortea Juan, Ismail Zahinoor, Baker Suzanne, Pascoal Tharick A, Rosa-Neto Pedro, HEAD Study
Аннотация
METHODS: We assessed 110 individuals with head-to-head [18F]MK6240 and [18F]Flortaucipir tau-PET. Voxel-wise and region-of-interest analyses investigated relationships between tau-PET and MBI Checklist (MBI-C) scores, which were also compared across tau-PET positivity and PET-Braak stages.
RESULTS: For both tracers, MBI severity was associated with tau-PET signal in all Braak regions and increased across PET-Braak stages. [18F]MK6240 showed more extensive voxel-wise associations with MBI-C scores and additional correlations with affective symptoms in stratified analyses by diagnostic groups. Tau positivity was associated with a higher frequency of MBI. Individuals positive for [18F]MK6240 but negative for [18F]Flortaucipir exhibited greater MBI burden than individuals negative for both tracers.
DISCUSSION: MBI in early AD is associated with tau-PET, with [18F]MK6240 providing greater sensitivity to detect MBI-related symptoms.