Neurology · 2007
Neuroimaging of neuronal circuits involved in tic generation in patients with Tourette syndrome.
СтатьяResearch Support, N.I.H., IntramuralНазвание и аннотация: Перевод пока не подготовлен
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Lerner A, Bagic A, Boudreau E A, Hanakawa T, Pagan F, Mari Z, Bara-Jimenez W, Aksu M, Garraux G, Simmons J M, Sato S, Murphy D L, Hallett M
Аннотация
OBJECTIVE: To identify brain regions generating tics in patients with Tourette syndrome using sleep as a baseline.
METHODS: We used [15O]H2O PET to study nine patients with Tourette syndrome and nine matched control subjects. For patients, conditions included tic release states and sleep stage 2; and for control subjects, rest states and sleep stage 2.
RESULTS: Our study showed robust activation of cerebellum, insula, thalamus, and putamen during tic release.
CONCLUSION: The network of structures involved in tics includes the activated regions and motor cortex. The prominent involvement of cerebellum and insula suggest their involvement in tic initiation and execution.
METHODS: We used [15O]H2O PET to study nine patients with Tourette syndrome and nine matched control subjects. For patients, conditions included tic release states and sleep stage 2; and for control subjects, rest states and sleep stage 2.
RESULTS: Our study showed robust activation of cerebellum, insula, thalamus, and putamen during tic release.
CONCLUSION: The network of structures involved in tics includes the activated regions and motor cortex. The prominent involvement of cerebellum and insula suggest their involvement in tic initiation and execution.