Neuro-endocrinal regulation and disorders of intracranial hemocirculation in rheumatic diseases in children.

The purpose of present work was detection of correlation between cerebrovascular complication and misbalance of noradrenergic-serotoninergic regulation in adolescents during primary rheumatism. A total of 23 children with the age range 10,2+/-1,3 years suffering from primary rheumatism and subjected to antibiotic and non-steroid anti-inflammatory treatment have been investigated using fluorometry and intra-cranial dopplerography. The control group involved practically healthy 10 adolescents with the average age of 11,8+/-2,3 years. Linear speed of blood flow in intra-dural segments of vertebral artery and basilar artery has been measured; concentration of epinephrine, norepinephrine, serotonin and dopamine was detected. Along with laboratory testing, patients were under observation in order to detect clinical manifestations (signs and symptoms of the prime disease and accompanied complication - cerebrovascular disorders). According to the results of experiments cerebrovascular complications in children suffering with primary rheumatism are frequently manifested by the chorea minor, which allows to surmise the increase of dopamine concentration in the structures of central nervous system. Accumulation of dopamine in brain structure makes good background for development of aggressiveness, chaotic movement, emotionality etc. Besides noradrenalin and dopamine concentrations were reduced and serotonin and epinephrine concentration were increases in blood plasma, which points to misbalance in adrenonergic and serotoninergic regulation in children with rheumatism.