Journal of Korean medical science · 2026
Epidemiological and Genotypic Trends of Enteric Adenovirus, Astrovirus, and Sapovirus in Gwangju, Korea, 2017-2023.
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Lim Mi Hyeon, Kim Min Ji, Lee Ji-Eun, Hwang Da Jeong, Lee Kwang Ho, Ha Yi-Deun, Gang Gyung-Li, Seong Jihyoun, Seo Jung-Mi
Аннотация
BACKGROUND: Acute gastroenteritis caused by enteric viruses remains a major public health concern, particularly in young children. While norovirus and group A rotavirus have been well investigated, data on enteric adenovirus, astrovirus, and sapovirus remain limited. This study aimed to investigate the long-term epidemiological and genotypic trends of enteric adenovirus (HAdV), astrovirus (HAstV), and sapovirus (SaV) in Gwangju, South Korea.
METHODS: A total of 16,531 stool samples were collected from patients with acute gastroenteritis between 2017 and 2023 through the national surveillance system. Viral detection and genotyping were performed using standardized molecular methods, and phylogenetic analysis was conducted for selected strains.
RESULTS: The overall positivity rates were 2.2% for HAdV, 2.5% for HAstV, and 1.0% for SaV. Detection dropped to the lowest levels in 2020 and increased sharply in 2021-2022, particularly in children aged 0-5 years. This pattern likely reflects the impact of COVID-19-related public health measures and their relaxation. Genotypic analysis revealed a predominance of HAdV-F41, HAstV type 1, and SaV GI.1. Notably, while HAstV and SaV exhibited genotype diversity before 2020, type 1 and GI.1 became dominant thereafter. Phylogenetic analysis demonstrated minimal genetic variation among dominant strains.
CONCLUSION: This seven-year surveillance highlights significant shifts in the prevalence and genotype distribution of underrecognized enteric viruses. The findings underscore the importance of sustained epidemiological and molecular monitoring to inform future public health strategies targeting enteric virus transmission.
METHODS: A total of 16,531 stool samples were collected from patients with acute gastroenteritis between 2017 and 2023 through the national surveillance system. Viral detection and genotyping were performed using standardized molecular methods, and phylogenetic analysis was conducted for selected strains.
RESULTS: The overall positivity rates were 2.2% for HAdV, 2.5% for HAstV, and 1.0% for SaV. Detection dropped to the lowest levels in 2020 and increased sharply in 2021-2022, particularly in children aged 0-5 years. This pattern likely reflects the impact of COVID-19-related public health measures and their relaxation. Genotypic analysis revealed a predominance of HAdV-F41, HAstV type 1, and SaV GI.1. Notably, while HAstV and SaV exhibited genotype diversity before 2020, type 1 and GI.1 became dominant thereafter. Phylogenetic analysis demonstrated minimal genetic variation among dominant strains.
CONCLUSION: This seven-year surveillance highlights significant shifts in the prevalence and genotype distribution of underrecognized enteric viruses. The findings underscore the importance of sustained epidemiological and molecular monitoring to inform future public health strategies targeting enteric virus transmission.