Leukemia research · 2006
Establishment of a novel B-cell lymphoma cell line with suppressed growth by gamma-secretase inhibitors.
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Tohda Shuji, Sato Taku, Kogoshi Hanae, Fu Lu, Sakano Seiji, Nara Nobuo
Аннотация
A novel lymphoma cell line, designated TMD8 was established from cells of a patient with diffuse large B-cell lymphoma. TMD8 cells expressed HES1 mRNA, suggesting constitutive activation of Notch signaling. TMD8 cells expressed normal-sized Notch1 protein, and showed no mutations in the NOTCH1 gene. Cell growth was suppressed by gamma-secretase inhibitors (GSI). It was reported that GSI suppressed growth of T-cell acute lymphoblastic leukemia (T-ALL) cell lines, which frequently had NOTCH1 mutations. In addition to T-ALL, TMD8 is another unique cell line sensitive to GSI, and is useful to study effects of GSI in molecular targeting therapy.
Предметные рубрики MeSH
Adaptor Proteins, Signal TransducingAmyloid Precursor Protein SecretasesBasic Helix-Loop-Helix ProteinsCalcium-Binding ProteinsCell Line, TumorCell ProliferationCell SurvivalDipeptidesEnzyme InhibitorsFatal OutcomeHomeodomain ProteinsHumansIntercellular Signaling Peptides and ProteinsJagged-2 ProteinKaryotypingLigandsLymphoma, B-CellMaleMembrane ProteinsMiddle AgedOligopeptidesRNA, MessengerReceptor, Notch1Receptor, Notch2Reverse Transcriptase Polymerase Chain ReactionStructure-Activity RelationshipTranscription Factor HES-1