Pathogens and disease · 2021
SARS-CoV-2 RT-PCR profile in 298 Indian COVID-19 patients: a retrospective observational study.
СтатьяНаблюдательное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Bhattacharya Bisakh, Kumar Rohit, Meena Ved Prakash, Soneja Manish, Singh Amit, Das Rojaleen, Xess Ashit, Arif Nazneen, Vig Saurabh, Rastogi Vandana, Tiwari Pavan, Bhatnagar Sushma, Mohan Anant, Wig Naveet, Dar Lalit
Аннотация
BACKGROUND: despite being in the 5th month of pandemic, knowledge with respect to viral dynamics, infectivity and RT-PCR positivity continues to evolve.
AIM: to analyse the SARS CoV-2 nucleic acid RT-PCR profiles in COVID-19 patients.
DESIGN: it was a retrospective, observational study conducted at COVID facilities under AIIMS, New Delhi.
METHODS: patients admitted with laboratory confirmed COVID-19 were eligible for enrolment. Patients with incomplete details, or only single PCR tests were excluded. Data regarding demographic details, comorbidities, treatment received and results of SARS-CoV-2 RT-PCR performed on nasopharyngeal and oropharyngeal swabs, collected at different time points, was retrieved from the hospital records.
RESULTS: a total of 298 patients were included, majority were males (75·8%) with mean age of 39·07 years (0·6-88 years). The mean duration from symptom onset to first positive RT-PCR was 4·7 days (SD 3·67), while that of symptom onset to last positive test was 17·83 days (SD 6·22). Proportions of positive RT-PCR tests were 100%, 49%, 24%, 8·7% and 20·6% in the 1st, 2nd, 3rd, 4th and >4 weeks of illness. A total of 12 symptomatic patients had prolonged positive test results even after 3 weeks of symptom onset. Age > = 60 years was associated with prolonged RT-PCR positivity (statistically significant).
CONCLUSION: this study showed that the average period of PCR positivity is more than 2 weeks in COVID-19 patients; elderly patients have prolonged duration of RT-PCR positivity and requires further follow up.
AIM: to analyse the SARS CoV-2 nucleic acid RT-PCR profiles in COVID-19 patients.
DESIGN: it was a retrospective, observational study conducted at COVID facilities under AIIMS, New Delhi.
METHODS: patients admitted with laboratory confirmed COVID-19 were eligible for enrolment. Patients with incomplete details, or only single PCR tests were excluded. Data regarding demographic details, comorbidities, treatment received and results of SARS-CoV-2 RT-PCR performed on nasopharyngeal and oropharyngeal swabs, collected at different time points, was retrieved from the hospital records.
RESULTS: a total of 298 patients were included, majority were males (75·8%) with mean age of 39·07 years (0·6-88 years). The mean duration from symptom onset to first positive RT-PCR was 4·7 days (SD 3·67), while that of symptom onset to last positive test was 17·83 days (SD 6·22). Proportions of positive RT-PCR tests were 100%, 49%, 24%, 8·7% and 20·6% in the 1st, 2nd, 3rd, 4th and >4 weeks of illness. A total of 12 symptomatic patients had prolonged positive test results even after 3 weeks of symptom onset. Age > = 60 years was associated with prolonged RT-PCR positivity (statistically significant).
CONCLUSION: this study showed that the average period of PCR positivity is more than 2 weeks in COVID-19 patients; elderly patients have prolonged duration of RT-PCR positivity and requires further follow up.
Предметные рубрики MeSH
AdolescentAdultAgedAged, 80 and overAsymptomatic DiseasesCOVID-19COVID-19 Nucleic Acid TestingChildChild, PreschoolComorbidityDiabetes MellitusHumansHypertensionIndiaInfantInfectious Disease Incubation PeriodMaleMiddle AgedNasopharynxOropharynxRNA, ViralRetrospective StudiesReverse Transcriptase Polymerase Chain ReactionSARS-CoV-2Severity of Illness Index