[Association of Chinese visceral adiposity index with bone mineral content and bone metabolic markers of middle school students in Yinchuan from 2017 to 2023].

OBJECTIVE

To investigate the relationship between the Chinese visceral adiposity index (CVAI), bone mineral content (BMC), and serum osteocalcin (OC) and type I collagen cross-linked C-terminal peptide (CTX) levels in Yinchuan middle school students.

METHODS

A total of 1603 students aged 12-18 years in Yinchuan City were selected as study subjects with a mean age of (14.99±1.51) years old in 2017-2023 by stratified clustering sampling, including 915(57.1%) boys, 1149(71.7%)Han, 201(12.5%)Hui and 191(11.9%) from other ethnic groups. Height and weight were measured, and total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were measured. The serum osteocalcin and type I collagen cross-linked C-terminal peptide were measured by enzyme linked immunosorbent assay (ELISA). Regression models combined with restricted cubic spline were used to analyze the relationship between CVAI and low bone mass and low bone metabolism markers among middle school students in Yinchuan City, and receiver operating characteristic(ROC) curves were used to analyze the effect of their assessment on low bone mass.

RESULTS

After adjusting for confounding factors of gender, age, smoking, alcohol consumption, physical activity and outdoor activity hours, the risk of low bone mass was lower in the Q4 of CVAI than in the Q1(OR=0.03, 95%CI 0.01-0.07), and the result were similar after stratification by gender (P<0.05); the risk of low OC in the Q4 of CVAI was higher than that in the Q1(OR=1.98, 95%CI 1.36-2.88), while the risk of low CTX was lower than that of Q1(OR=0.52, 95%CI 0.36-0.75, P<0.05). A linear dose-response relationship was observed between CVAI and low bone mass and low CTX (Poverall trend<0.05, Pnonlinearity>0.05), while a nonlinear dose-response relationship was found between CVAI and low OC(Poverall trend<0.05, Pnonlinearity<0.05). The ROC curve analysis revealed that CVAI had the best diagnostic performance for low bone mass (AUC=0.87, 95%CI 0.85-0.90, P<0.05).

CONCLUSION

Increased CVAI can reduce the risk of low bone mass and low CTX, and increase the risk of low OC in Yinchuan middle school students.