Cell · 2021

Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy.

СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди

Обработка статьи · этапы, ошибки и управление

Загрузка состояния…

История · было → стало

Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.

Béziat Vivien, Rapaport Franck, Hu Jiafen, Titeux Matthias, Bonnet des Claustres Mathilde, Bourgey Mathieu, Griffin Heather, Bandet Élise, Ma Cindy S, Sherkat Roya, Rokni-Zadeh Hassan, Louis David M, Changi-Ashtiani Majid, Delmonte Ottavia M, Fukushima Toshiaki, Habib Tanwir, Guennoun Andrea, Khan Taushif, Bender Noemi, Rahman Mahbuba, About Frédégonde, Yang Rui, Rao Geetha, Rouzaud Claire, Li Jingwei, Shearer Debra, Balogh Karla, Al Ali Fatima, Ata Manar, Dabiri Soroosh, Momenilandi Mana, Nammour Justine, Alyanakian Marie-Alexandra, Leruez-Ville Marianne, Guenat David, Materna Marie, Marcot Léa, Vladikine Natasha, Soret Christine, Vahidnezhad Hassan, Youssefian Leila, Saeidian Amir Hossein, Uitto Jouni, Catherinot Émilie, Navabi Shadi Sadat, Zarhrate Mohammed, Woodley David T, Jeljeli Mohamed, Abraham Thomas, Belkaya Serkan, Lorenzo Lazaro, Rosain Jérémie, Bayat Mousa, Lanternier Fanny, Lortholary Olivier, Zakavi Faramarz, Gros Philippe, Orth Gérard, Abel Laurent, Prétet Jean-Luc, Fraitag Sylvie, Jouanguy Emmanuelle, Davis Mark M, Tangye Stuart G, Notarangelo Luigi D, Marr Nico, Waterboer Tim, Langlais David, Doorbar John, Hovnanian Alain, Christensen Neil, Bossuyt Xavier, Shahrooei Mohammad, Casanova Jean-Laurent

Аннотация

We study a patient with the human papilloma virus (HPV)-2-driven "tree-man" phenotype and two relatives with unusually severe HPV4-driven warts. The giant horns form an HPV-2-driven multifocal benign epithelial tumor overexpressing viral oncogenes in the epidermis basal layer. The patients are unexpectedly homozygous for a private CD28 variant. They have no detectable CD28 on their T cells, with the exception of a small contingent of revertant memory CD4+ T cells. T cell development is barely affected, and T cells respond to CD3 and CD2, but not CD28, costimulation. Although the patients do not display HPV-2- and HPV-4-reactive CD4+ T cells in vitro, they make antibodies specific for both viruses in vivo. CD28-deficient mice are susceptible to cutaneous infections with the mouse papillomavirus MmuPV1. The control of HPV-2 and HPV-4 in keratinocytes is dependent on the T cell CD28 co-activation pathway. Surprisingly, human CD28-dependent T cell responses are largely redundant for protective immunity.

Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy.

Ошибки и ограничения

Аннотация

Предметные рубрики MeSH